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Table 3 Immunohistochemical characteristics and their association with loss of wt BRCA1 in ER-positive and ER-negative BRCA1-related breast cancers

From: Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers

Variable

ER+

ER-

 

Loss of wt BRCA1N(%)

No loss of wt BRCA1N(%)

P-value

Loss of wt BRCA1N(%)

No loss of wt BRCA1

N(%)

P-value

Cytokeratins

      

CK5/6

(31)

(7)

0.164

(27)

(4)

0.010

   Positive

9 (29.0)

0

 

20 (74.1)

0

 

   Negative

22 (71.0)

7 (100)

 

7 (25.9)

4 (100)

 

CK7/8

(31)

(8)

---

(28)

(4)

1.0

   Positive

31 (100)

8 (100)

 

25 (89.3)

4 (100)

 

   Negative

0

0

 

3 (10.7)

0

 

CK14

(31)

(6)

0.566

(27)

(3)

0.054

   Positive

5 (16.1)

0

 

18 (66.7)

0

 

   Negative

26 (83.9)

6 (100)

 

9 (33.3)

3(100)

 

CK5/6 or CK14

(33)

(8)

0.083

(27)

(4)

0.001*

   Positive

11 (33.3)

0

 

24 (88.9)

0

 

   Negative

22 (66.7)

8 (100)

 

3 (11.1)

4 (100)

 

CK 18

(32)

(7)

----

(27)

(4)

1.00

   Positive

32 (100)

7 (100)

 

26 (96.3)

4 (100)

 

   Negative

0

0

 

1 (3.7)

0

 

CK19

(33)

(6)

----

(28)

(4)

0.125

   Positive

33 (100)

6 (100)

 

28 (100)

3 (75)

 

   Negative

0

0

 

0

1 (25)

 

EGFR

(30)

(7)

0.560

(26)

(4)

0.360

   Positive

5 (16.7)

0

 

24 (92.3)

3(75)

 

   Negative

25 (83.3)

7 (100)

 

2 (7.7)

1 (25)

 

CK5/6 and/or CK14 and/or EGFR

(33)

(8)

0.083

(28)

(4)

0.125

   Positive

11 (33.3)

0

 

28 (100)

3 (75)

 

   Negative

22 (66.7)

8 (100)

 

0

1 (25)

 

P53

(30)

(7)

1.00

(26)

(4)

0.601

   Positive

14 (46.7)

4 (57.1)

 

13 (50)

3 (75)

 

   Negative

16 (53.3)

3 (42.9)

 

13 (50)

1 (25)

 
  1. Abbreviations: ER, estrogen receptor; CK, cytokeratin; EGFR, epidermal growth factor receptor.
  2. Loss of wt: cancers with LOH with loss of wt BRCA1 allele.
  3. No loss of wt: includes cancers with no LOH and LOHmut .
  4. *P-value retained significance with Bonferroni adjustment for multiple comparisons.
  5. Percentages calculated by column.