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Table 1 Limiting dilution tumor formation of parental, hypoxia-exposed adherent, and cycling hypoxia-selected breast cancer cells in vivo

From: Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation

Cell type Days Number injected and tumors formed
   5 × 105 5 × 104 5 × 103 5 × 102
MDA-MB 231 (total cell population) 24-90 5/6 2/6 0/5 0/5
MDA-MB 231 A3 (hypoxia-exposed adherent cells) 90 - - - 0/5
MDA-MB 231 F3 (cycling hypoxia-selected subpopulation) 10-90 6/6 6/6 5/5 4/5
BCM2 (total cell population) 35-98 - 5/5 - 0/5
BCM2 A3 (hypoxia-exposed adherent cells) 98 - - - 0/5
BCM2 F3 (cycling hypoxia-selected subpopulation) 28-98 - 5/5 - 4/5