Figure 2
Growth curves of primary tumors generated from the parental cell lines and cycling hypoxia-selected subpopulations. (a) Growth curves of primary tumors in non-obese diabetic/severe combined immunodeficiency disease (NOD/SCID) mice injected with 5 × 105 or 5 × 104 MDA-MB 231 and MDA-MB 231 F3 cells. Tumors were first detected by palpation. Standard errors are derived from duplicate experiments (n = 6 per cell number for each experiment). (b) Growth curves of tumors in NOD/SCID mice injected with 5 × 103 or 5 × 102 MDA-MB 231 and MDA-MB 231 F3 cells. Standard errors were derived from duplicate experiments (n = 5 per cell number for each experiment). (c) Growth curves of tumors in NOD/SCID mice injected with 5 × 104 or 5 × 102 BCM2 and BCM2 F3 cells. Standard errors were derived from duplicate experiments (n = 5 per cell number for each experiment).