A genome-wide association scan on estrogen receptor-negative breast cancer

Breast Cancer Research

Table 2 Top ranking pathways of genome-wide pathway analysis results using SNP ratio test (P < 0.1)

KEGG ID	Pathway name Class	No. of SNPs P< 0.05	No. of SNPs in pathway	Number of significantly associated SNPs with P
				E-05	E-04	E-03	E-02	P
00040	Pentose and glucuronate interconversions Metabolism; Carbohydrate Metabolism	11	63	0	1	2	8	0.022
04540	Gap junction Cellular Processes; Cell Communication	95	1,366	1	0	16	78	0.037
00500	Starch and sucrose metabolism Metabolism; Carbohydrate Metabolism	22	237	0	2	4	16	0.042
00604	Glycosphingolipid biosynthesis ganglio series Metabolism; Glycan Biosynthesis and Metabolism	20	216	0	0	4	16	0.051
00230	Purine metabolism Metabolism; Nucleotide Metabolism	106	1,618	1	2	16	87	0.054
04130	SNARE interactions in vesicular transport Genetic Information Processing; Folding, Sorting and Degradation	19	206	0	4	1	14	0.060
03022	Basal transcription factors Genetic Information Processing; Transcription	11	105	0	0	4	7	0.062
04910	Insulin signaling pathway Cellular Processes; Endocrine System	61	889	2	6	9	44	0.071
04350	TGF-beta signaling pathway Environmental Information Processing; Signal Transduction	43	586	0	1	9	33	0.077
04330	Notch signaling pathway Environmental Information Processing; Signal Transduction	25	321	0	0	4	21	0.087
04614	Renin-angiotensin system Cellular Processes; Endocrine System	8	78	0	0	1	7	0.092

KEGG ID, Kyoto Encyclopedia of Genes and Genomes pathway identifier (hsa*); P, P-value of permutation test; SNP, single nucleotide polymorphism

ISSN: 1465-542X