Figure 10

Proportion of shared polygenic component between breast cancer estrogen receptor subtypes. Proportion of shared polygenic component between ER-positive and ER-negative target samples, with respect to their corresponding ER-positive training samples. Pt denotes P-value cut-off in training sample. a) Test for association between polygenic score and disease status (ER-positive/ER-negative) in the Swedish data, when all SNPs with P < 0.5 in the Finnish training set were considered. b) Test for association between polygenic score and disease status (ER-positive/ER-negative) in the Finnish data, when all SNPs with P < 0.5 in the Swedish training set were considered. c) Significance test for difference in scores (Finnish ER-positive breast cancers derived) between Swedish ER-negative and ER-positive breast cancers, adjusted for number of non-missing genotypes. Significance codes: '- ' 0.1 <P < 1 (that is, not significant). d) Significance test for difference in scores (Swedish ER-positive breast cancers derived) between Finnish ER-negative and ER-positive breast cancers, adjusted for number of non-missing genotypes. Significance codes: '*' 0.01 <P < 0.05.