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Figure 2 | Breast Cancer Research

Figure 2

From: Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

Figure 2

Inhibition of ERK1/2 phosphorylation increases RUNX2 protein levels in MDA-MB-231 cells. The coupling between mitogenic signaling pathways and RUNX2 protein expression was examined in MDA-MB-231 (A) or MCF7 cells (B). Each cell type was treated with the MEK1 inhibitor PD98059 for 2 h at the indicated concentrations (in μM). The protein levels of RUNX2, phospho-ERK, total ERK1/2, p21 and GAPDH were analyzed by western blotting. RUNX2 protein levels remained below the level of detection in MCF7 cells (B, top panel).

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Breast Cancer Research

ISSN: 1465-542X

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