Table 3 Correlations (Rp) between the HRneg/Tneg and IR-7 prognostic indices with T- and B-lymphocyte gene signatures in the training and validation tumor cohorts
| Â | Training cohort (n= 199) | Validation cohort (n= 75) | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | HRneg/Tneg | IR-7 | HRneg/Tneg | IR-7 | ||||
Lymphocyte-specific signatures | Rp | P value | Rp | P value | Rp | P value | Rp | P value |
T-cell signature | -0.31 | 1.18 × 10-5 | -0.65 | < 2.2 × 10-16 | -0.41 | 2.83 × 10-4 | -0.62 | 3.439 × 10-9 |
T-cell co-receptor components | -0.39 | 9.28 × 10-9 | -0.73 | < 2.2 × 10-16 | -0.42 | 1.78 × 10-4 | -0.66 | 7.888 × 10-11 |
B-cell signature | -0.33 | 2.74 × 10-6 | -0.89 | < 2.2 × 10-16 | -0.43 | 1.20 × 10-4 | -0.77 | 9.07 × 10-16 |
B-cell surface co-receptor/marker | -0.15 | 2.94 × 10-2 | -0.63 | < 2.2 × 10-16 | -0.34 | 2.60 × 10-3 | -0.79 | < 2.2 × 10-16 |