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Table 3 Correlations (Rp) between the HRneg/Tneg and IR-7 prognostic indices with T- and B-lymphocyte gene signatures in the training and validation tumor cohorts

From: A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer

  Training cohort (n= 199) Validation cohort (n= 75)
  HRneg/Tneg IR-7 HRneg/Tneg IR-7
Lymphocyte-specific signatures Rp P value Rp P value Rp P value Rp P value
T-cell signature -0.31 1.18 × 10-5 -0.65 < 2.2 × 10-16 -0.41 2.83 × 10-4 -0.62 3.439 × 10-9
T-cell co-receptor components -0.39 9.28 × 10-9 -0.73 < 2.2 × 10-16 -0.42 1.78 × 10-4 -0.66 7.888 × 10-11
B-cell signature -0.33 2.74 × 10-6 -0.89 < 2.2 × 10-16 -0.43 1.20 × 10-4 -0.77 9.07 × 10-16
B-cell surface co-receptor/marker -0.15 2.94 × 10-2 -0.63 < 2.2 × 10-16 -0.34 2.60 × 10-3 -0.79 < 2.2 × 10-16
  1. HRneg, hormone receptor-negative; IR-7, immune response signature with 7-gene immune response module; Rp, Pearson correlation coefficient; Tneg, triple-negative.