Figure 4
Functional network connections between HRneg/Tneg signature genes. (a) Pathway diagram linking HRneg/Tneg genes with common upstream regulators. (b) Pathway diagram linking HRneg/Tneg genes with common downstream effectors. (c) Pathway diagram linking HRneg/Tneg genes by their shortest path. (a-c) Genes associated with positive hazard ratios are red, and those associated with negative hazard ratios are green. Arrows with + denote upregulation, and those with â”´ denote inhibition. Solid lines signify direct gene-gene interactions, and broken lines represent relationships that may require secondary effectors not depicted in the network. HRneg, hormone receptor-negative; Tneg, triple-negative.