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Table 1 Summary of microarray data for enzymes associated with choline metabolism

From: 17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Enzyme type

Gene symbol

Gene title

Percentage control

FDR

Choline transport

SLC5A7

Solute carrier family 5 (choline transporter), member 7

101

0.91

 

SLC44A1

Solute carrier family 44, member 1

154a

2.10 × 10-6

 

SLC22A1

Solute carrier family 22 (organic cation transporter), member 1

99

0.97

 

SLC22A2

Solute carrier family 22 (organic cation transporter), member 2

97

0.81

Choline kinase

CHKA

Choline kinase alpha

109

0.2

 

CHKB

Choline kinase beta

102

0.86

CTP:PC cytidylyltransferase

PCYT1A

Phosphate cytidylyltransferase 1, choline, alpha

101

0.92

 

PCYT1B

Phosphate cytidylyltransferase 1, choline, beta

109

0.35

Diacylglycerol choline-phosphotransferase

CHPT1

Choline phosphotransferase 1

146a

2.4 × 10-4

Phospholipase A

PLA1A

Phospholipase A1 member A

121a

0.05

 

PLA2G1B

Phospholipase A2, group IB (pancreas)

105

0.67

 

PLA2G2A

Phospholipase A2, group IIA (platelets, synovial fluid)

101

0.96

 

PLA2G2C

Phospholipase A2, group IIC

104

0.83

 

PLA2G2D

Phospholipase A2, group IID

98

0.83

 

PLA2G2E

Phospholipase A2, group IIE

98

0.91

 

PLA2G3

Phospholipase A2, group III

99

0.18

 

PLA2G4C

Phospholipase A2, group IVC (cytosolic, calcium-independent)

75a

0.0043

 

PLA2G4E

Phospholipase A2, group IVE

101

0.95

 

PLA2G4F

Phospholipase A2, group IVF

82a

0.018

 

PLA2G5

Phospholipase A2, group V

97

0.87

 

PLA2G6

Phospholipase A2, group VI (cytosolic, calcium-independent)

129

0.0067

 

PLA2G7

Phospholipase A2, group VII

112

0.3

 

PLA2G10

Phospholipase A2, group X

712a

1.60 × 10-8

 

PLA2G12A

Phospholipase A2, group XIIA

87a

0.03

 

PLA2G12B

Phospholipase A2, group XIIB

106

0.51

 

PLA2G15

Phospholipase A2, group XV

139

0.00043

 

PLA2G16

Phospholipase A2, group XVI

131

0.0021

Phospholipase

PLD1

Phospholipase D1, phosphatidylcholine-specific

137a

0.0038

 

PLD2

Phospholipase D2

106

0.68

 

PLD3

phospholipase D family, member 3

179a

7.80 × 10-7

 

PLD4

Phospholipase D family, member 4

106

0.68

 

PLD5

Phospholipase D family, member 5

116

0.1

 

PLD6

Phospholipase D family, member 6

82a

0.0036

Lysophospholipase

LYPLA1

Lysophospholipase I

90

0.13

 

LYPLAL1

Lysophospholipase-like 1

88

0.18

 

LYPLA2

Lysophospholipase II

90

0.14

Glycero phosphocholin phosphodiesterase

GDPD1

Glycerophosphodiester phosphodiesterase domain containing 1

106

0.64

 

GDPD2

Glycerophosphodiester phosphodiesterase domain containing 2

228a

1.2 × 10-6

 

GDPD3

Glycerophosphodiester phosphodiesterase domain containing 3

142a

2.6 × 10-7

 

GDPD5

Glycerophosphodiester phosphodiesterase domain containing 5

116

0.18

 

GDE1

Glycerophosphodiester phosphodiesterase 1

112

0.062

  1. aThese enzymes had a statistically significant (false discovery rate [FDR] less than or equal to 0.05) modulation in expression with 17-allyamino-17-demethoxygeldanamycin (17-AAG) treatment.