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Table 1 Summary of microarray data for enzymes associated with choline metabolism

From: 17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Enzyme type Gene symbol Gene title Percentage control FDR
Choline transport SLC5A7 Solute carrier family 5 (choline transporter), member 7 101 0.91
  SLC44A1 Solute carrier family 44, member 1 154a 2.10 × 10-6
  SLC22A1 Solute carrier family 22 (organic cation transporter), member 1 99 0.97
  SLC22A2 Solute carrier family 22 (organic cation transporter), member 2 97 0.81
Choline kinase CHKA Choline kinase alpha 109 0.2
  CHKB Choline kinase beta 102 0.86
CTP:PC cytidylyltransferase PCYT1A Phosphate cytidylyltransferase 1, choline, alpha 101 0.92
  PCYT1B Phosphate cytidylyltransferase 1, choline, beta 109 0.35
Diacylglycerol choline-phosphotransferase CHPT1 Choline phosphotransferase 1 146a 2.4 × 10-4
Phospholipase A PLA1A Phospholipase A1 member A 121a 0.05
  PLA2G1B Phospholipase A2, group IB (pancreas) 105 0.67
  PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid) 101 0.96
  PLA2G2C Phospholipase A2, group IIC 104 0.83
  PLA2G2D Phospholipase A2, group IID 98 0.83
  PLA2G2E Phospholipase A2, group IIE 98 0.91
  PLA2G3 Phospholipase A2, group III 99 0.18
  PLA2G4C Phospholipase A2, group IVC (cytosolic, calcium-independent) 75a 0.0043
  PLA2G4E Phospholipase A2, group IVE 101 0.95
  PLA2G4F Phospholipase A2, group IVF 82a 0.018
  PLA2G5 Phospholipase A2, group V 97 0.87
  PLA2G6 Phospholipase A2, group VI (cytosolic, calcium-independent) 129 0.0067
  PLA2G7 Phospholipase A2, group VII 112 0.3
  PLA2G10 Phospholipase A2, group X 712a 1.60 × 10-8
  PLA2G12A Phospholipase A2, group XIIA 87a 0.03
  PLA2G12B Phospholipase A2, group XIIB 106 0.51
  PLA2G15 Phospholipase A2, group XV 139 0.00043
  PLA2G16 Phospholipase A2, group XVI 131 0.0021
Phospholipase PLD1 Phospholipase D1, phosphatidylcholine-specific 137a 0.0038
  PLD2 Phospholipase D2 106 0.68
  PLD3 phospholipase D family, member 3 179a 7.80 × 10-7
  PLD4 Phospholipase D family, member 4 106 0.68
  PLD5 Phospholipase D family, member 5 116 0.1
  PLD6 Phospholipase D family, member 6 82a 0.0036
Lysophospholipase LYPLA1 Lysophospholipase I 90 0.13
  LYPLAL1 Lysophospholipase-like 1 88 0.18
  LYPLA2 Lysophospholipase II 90 0.14
Glycero phosphocholin phosphodiesterase GDPD1 Glycerophosphodiester phosphodiesterase domain containing 1 106 0.64
  GDPD2 Glycerophosphodiester phosphodiesterase domain containing 2 228a 1.2 × 10-6
  GDPD3 Glycerophosphodiester phosphodiesterase domain containing 3 142a 2.6 × 10-7
  GDPD5 Glycerophosphodiester phosphodiesterase domain containing 5 116 0.18
  GDE1 Glycerophosphodiester phosphodiesterase 1 112 0.062
  1. aThese enzymes had a statistically significant (false discovery rate [FDR] less than or equal to 0.05) modulation in expression with 17-allyamino-17-demethoxygeldanamycin (17-AAG) treatment.
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Breast Cancer Research

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