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Table 2 Tocotrienol intake and risk of breast cancer-specific death/recurrence in women with early breast cancer and estrogen receptor-positive tumors receiving tamoxifen

From: Effectiveness of tocotrienol-rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial

 

Type of treatment received along with tamoxifen

 

Placebo (n= 120)

Tocotrienol (n= 120)

Breast cancer-related death

  

   Number of patients (n (%))

6 (5.0)

2 (1.7)

   Crude hazard ratio

1.00

0.33 (95% CI, 0.07 to 1.61)

   Adjusted hazard ratioa

1.00

0.40 (95% CI, 0.08 to 2.05)

Local/systemic recurrence of breast cancer

  

   Number of patients (n (%))

20 (16.7)

16 (13.3)

   Crude hazard ratio

1.00

0.80 (95% CI, 0.41 to 1.54)

   Adjusted hazard ratioa

1.00

0.84 (95% CI, 0.43 to 1.65)

  1. aAdjusted for age (continuous), ethnicity (Malay, Chinese, Indian), TNM stage (stage 1, stage 2), and lymph node involvement (yes, no).