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Table 4 Silver in situ hybridization results for breast cancer cases showing HER2 receptor conversion in distant metastases by immunohistochemistry or 2+ scores by immunohistochemistry in either the primary tumor or the metastasis

From: Receptor conversion in distant breast cancer metastases

Case

HER2 (IHC)

primary tumor

HER2 (SISH)

primary tumor

HER2 (IHC)

metastasis

HER2 (SISH)

metastasis

Metastatic site

1

0

No amplification

2+

No signal

lung

2

0

No amplification

2+

No signal

liver

3

0

High amplification

3+

High amplification

liver

4

0

Low amplification

3+

Low amplification

skin

5

1+

No amplification

2+

High amplification

lung

6

1+

No amplification

2+

No amplification

skin

7

1+

No amplification

3+

High amplification

skin

8

1+

No amplification

3+

High amplification

liver

9

2+

High amplification

2+

High amplification

liver

10

2+

High amplification

2+

High amplification

liver

11

2+

Low amplification

2+

Low amplification

liver

12

2+

Low amplification

3+

High amplification

liver

13

2+

Low amplification

3+

High amplification

liver

14

3+

High amplification

0

No amplification

liver

15

3+

High amplification

0

No amplification

liver

16

3+

High amplification

0

No amplification

gastro-intestinal

17

3+

High amplification

2+

High amplification

brain

18

3+

High amplification

2+

No signal

lung

19

3+

High amplification

2+

High amplification

lung

  1. HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; SISH, silver in situ hybridization.