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Table 4 Silver in situ hybridization results for breast cancer cases showing HER2 receptor conversion in distant metastases by immunohistochemistry or 2+ scores by immunohistochemistry in either the primary tumor or the metastasis

From: Receptor conversion in distant breast cancer metastases

Case HER2 (IHC)
primary tumor
HER2 (SISH)
primary tumor
HER2 (IHC)
metastasis
HER2 (SISH)
metastasis
Metastatic site
1 0 No amplification 2+ No signal lung
2 0 No amplification 2+ No signal liver
3 0 High amplification 3+ High amplification liver
4 0 Low amplification 3+ Low amplification skin
5 1+ No amplification 2+ High amplification lung
6 1+ No amplification 2+ No amplification skin
7 1+ No amplification 3+ High amplification skin
8 1+ No amplification 3+ High amplification liver
9 2+ High amplification 2+ High amplification liver
10 2+ High amplification 2+ High amplification liver
11 2+ Low amplification 2+ Low amplification liver
12 2+ Low amplification 3+ High amplification liver
13 2+ Low amplification 3+ High amplification liver
14 3+ High amplification 0 No amplification liver
15 3+ High amplification 0 No amplification liver
16 3+ High amplification 0 No amplification gastro-intestinal
17 3+ High amplification 2+ High amplification brain
18 3+ High amplification 2+ No signal lung
19 3+ High amplification 2+ High amplification lung
  1. HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; SISH, silver in situ hybridization.