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Table 2 HER2 and ERα, PR expression by immunohistochemistry in paired primary breast cancers and their distant metastases

From: Receptor conversion in distant breast cancer metastases

   Distant metastases
Primary tumor Status - + Total
HER2 - 180 (77.2%) 6 (2.6%) 186
  + 6 (2.6%) 41 (17.6%) 47
   10% threshold 1% threshold
   - + Total - + total
ERα - 79 (33.9%) 7 (3.0%) 86 47 (20.2%) 12 (5.2%) 59
  + 17 (7.3%) 130 (55.8%) 147 23 (9.9%) 151 (64.8%) 147
PR - 92 (39.5%) 12 (5.1%) 104 33 (14.2%) 27 (11.6%) 60
  + 58 (24.9%) 71 (30.5%) 129 49 (21.0%) 124 (53.2%) 173
  1. For ERα and PR, data are shown using both the traditional 10% and new ASCO 1% thresholds.
  2. HER2, human epidermal growth factor receptor 2; ERα, estrogen receptor alpha; PR, progesterone receptor.