Figure 7From: Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomyDevelopment of edema following popliteal lymph node excision in the presence and absence of growth factor therapy. (a) Typical examples of edema formation in each treatment group (n = 1) are displayed. (b) The area under the curve (AUC) was calculated for animals using the trapezoidal rule. Node removal (nodectomy (2)) and node removal with HAMC (3) usually resulted in a sharp increase in edema formation over the first week and decreased marginally over the next 5 wk. In contrast, growth factor-treated groups displayed reduced edema levels by 6 wk (4), statistically similar to sham levels (1). Each bar represents mean ± SEM. Sham n = 18, nodectomy n = 36, HAMC n = 7, HAMC + GF n = 7. Significance in comparison to sham levels was assessed by ANOVA and Dunnett's one sided t-test. *P < 0.05.Back to article page