Clinical and pathological characteristics and prognosis of all intrinsic subtypes, including claudin-low tumors, across three independent breast cancer data sets. (a) Percentages of the different clinical-pathological characteristics in the UNC337 data set and two publicly available data sets (NKI295 and MDACC133). ER/PR/HER2 scores of the UNC337 database were based on clinically validated methods. (b) Survival data of the different molecular subtypes are shown for the UNC337 database and NKI295. Normal breast-like samples have been removed from this analysis. The UNC337 set represents a heterogeneously treated group of patients treated in accord with the biomarker status, whereas NKI295 is predominantly a local therapy only cohort.