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Figure 6 | Breast Cancer Research

Figure 6

From: Penta-O-galloyl-β-D-glucose induces G1arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth

Figure 6

Effect of PGG on G 0/1 -S progression in synchronized MCF-7 cells. (a) The temporal kinetics of serum-stimulated progression of starvation-synchronized MCF-7 cells. Each time point was the average of duplicate flasks. *,#P < 0.05; **,##P < 0.01; ***,###P < 0.001 versus 0 time. (b) Impact of delaying PGG treatment with reference to serum stimulation on G1 arrest. Results are from two independent experiments with duplicate values at each time point. *,#P < 0.05; **,##P < 0.01 versus serum-free (SF) or PGG@0h-14 h. CM, complete medium; PGG, penta-O-galloyl-β-D-glucose.

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