Skip to main content
Figure 5 | Breast Cancer Research

Figure 5

From: Penta-O-galloyl-β-D-glucose induces G1arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth

Figure 5

Impact of overexpression of cyclin D1 on PGG-induced G 1 arrest in MCF-7 and MDA-MB231 cells. (a) Western blot verification of stable overexpression of cyclin D1 in MCF-7 and MDA-MB231 cells. (b) Cell cycle distribution of MCF-7 cells transfected with vector and cyclin D1 plasmid with or without PGG treatment for 24 hours. (c) Cell cycle distribution of MDA-MB231 cells transfected with vector and cyclin D1 plasmid with or without PGG treatment for 24 hours. Each bar reflects the average of two T25 flasks. The patterns are representative of two experiments. PGG, penta-O-galloyl-β-D-glucose.

Back to article page