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Figure 4 | Breast Cancer Research

Figure 4

From: Penta-O-galloyl-β-D-glucose induces G1arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth

Figure 4

The effect of PGG on cell cycle proteins in serum starvation-synchronized MCF-7 cells. PGG was included at time of serum stimulation (as time 0). Western blot was used to detect Cyclin D1 expression and phosphorylation of Retinoblastoma protein, activation of P53-Ser15P, and expressions of P21Cip1 and estrogen receptor-alpha. cPARP, cleaved poly-ADP-ribose polymerase; ERα, estrogen receptor-alpha; FBS, fetal bovine serum; P21Cip1, cyclin-dependent kinase inhibitor 1A; PGG, penta-O-galloyl-β-D-glucose.

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Breast Cancer Research

ISSN: 1465-542X

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