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Table 2 Linear regression analysis of factors predicting mammographic density in all women and stratified for age and hormone therapy use

From: Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density

Women in model N Variables Beta value P value
All women 76 UGT2B101) -0.6 0.902
   UGT2B7 1.8 0.631
   UGT2B11 4.8 0.275
   ESR1 -3.8 0.055
   UGT2B10 2) -5.6 0.005
   BMI -1.5 0.015
   age -0.4 0.074
50 years or older 46 UGT2B11 0.2 0.987
   UGT2B101) 1.0 0.946
   UGT2B7 3.5 0.486
   UGT2B102) -3.7 0.073
   BMI -1.4 0.052
   ESR1 -6.0 0.016
   age -0.9 0.061
50 years or older, currently on hormone therapy 11 UGT2B101) 7.2 0.771
   UGT2B11 -5.8 0.695
   BMI -2.9 0.103
   UGT2B7 6.8 0.418
   UGT2B10 2) -27.0 0.000
   ESR1 -8.1 0.011
   age -0.9 0.103
50 years or older, never used hormone therapy 28 UGT2B11 -0.7 0.948
   UGT2B101) 3.3 0.809
   UGT2B7 3.1 0.555
   UGT2B102) -1.4 0.607
   BMI -0.9 0.348
   ESR1 -6.0 0.033
   Age -1.5 0.004
Younger than 50 years 30 UGT2B7 0.4 0.950
   UGT2B101) -1.2 0.866
   ESR1 -0.9 0.835
   UGT2B11 8.4 0.225
   BMI -1.4 0.216
   UGT2B10 2) -6.2 0.040
   Age -0.3 0.610
  1. 1) A_24_P521559, 2) A_23_P7342
  2. Factors predicting mammographic density (MD) after stepwise exclusion of non-significant factors are shown. Variables listed in the order of exclusion from the model. P value from the last equation including the variable is shown. Age is forced to stay in the model. UGT2B10 (A_23_P7342) is a significant, independent predictor of MD in all analyses with a majority of women under influence of female hormones; women younger than 50 years of age and women currently on hormone therapy. BMI, body mass index.