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Table 2 Linear regression analysis of factors predicting mammographic density in all women and stratified for age and hormone therapy use

From: Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density

Women in model

N

Variables

Beta value

P value

All women

76

UGT2B101)

-0.6

0.902

  

UGT2B7

1.8

0.631

  

UGT2B11

4.8

0.275

  

ESR1

-3.8

0.055

  

UGT2B10 2)

-5.6

0.005

  

BMI

-1.5

0.015

  

age

-0.4

0.074

50 years or older

46

UGT2B11

0.2

0.987

  

UGT2B101)

1.0

0.946

  

UGT2B7

3.5

0.486

  

UGT2B102)

-3.7

0.073

  

BMI

-1.4

0.052

  

ESR1

-6.0

0.016

  

age

-0.9

0.061

50 years or older, currently on hormone therapy

11

UGT2B101)

7.2

0.771

  

UGT2B11

-5.8

0.695

  

BMI

-2.9

0.103

  

UGT2B7

6.8

0.418

  

UGT2B10 2)

-27.0

0.000

  

ESR1

-8.1

0.011

  

age

-0.9

0.103

50 years or older, never used hormone therapy

28

UGT2B11

-0.7

0.948

  

UGT2B101)

3.3

0.809

  

UGT2B7

3.1

0.555

  

UGT2B102)

-1.4

0.607

  

BMI

-0.9

0.348

  

ESR1

-6.0

0.033

  

Age

-1.5

0.004

Younger than 50 years

30

UGT2B7

0.4

0.950

  

UGT2B101)

-1.2

0.866

  

ESR1

-0.9

0.835

  

UGT2B11

8.4

0.225

  

BMI

-1.4

0.216

  

UGT2B10 2)

-6.2

0.040

  

Age

-0.3

0.610

  1. 1) A_24_P521559, 2) A_23_P7342
  2. Factors predicting mammographic density (MD) after stepwise exclusion of non-significant factors are shown. Variables listed in the order of exclusion from the model. P value from the last equation including the variable is shown. Age is forced to stay in the model. UGT2B10 (A_23_P7342) is a significant, independent predictor of MD in all analyses with a majority of women under influence of female hormones; women younger than 50 years of age and women currently on hormone therapy. BMI, body mass index.