|  |  | No tamoxifen (unadjusted) | All tamoxifen-treated patients (unadjusted) | ER-positive patients treated with tamoxifen (unadjusted) | ER-positive patients treated with tamoxifen (adjusted) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
†SNP | Metaboliser Status | MAF** | P-value | Hazard ratio | 95% CI** | P-value | Hazard ratio | 95% CI** | P-value | Hazard ratio | 95% CI** | P-value | Hazard ratio | 95% CI** |
CYP2D6 functional SNPs | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
CYP2D6*41 | (IM) | 0.09 | 0.89 | 1.02 | 0.72-1.46 | 0.12 | 0.79 | 0.59-1.07 | 0.43 | 0.85 | 0.57-1.27 | 0.69 | 0.88 | 0.48-1.62 |
CYP2D6*4 | (PM) | 0.2 | 0.34 | 0.88 | 0.69-1.15 | 0.89 | 1.01 | 0.83-1.24 | 0.93 | 1.01 | 0.78-1.32 | 0.39 | 1.17 | 0.82-1.68 |
CYP2D6*5 | (PM) | 0.04 | 0.49 | 2.01 | 0.28-14.3 | †n/a | †n/a | †n/a | †n/a | †n/a | †n/a | †n/a | †n/a | †n/a |
‡CYP2D6*6 | (PM) | 0.01 | 0.76 | 1.17 | 0.43-3.14 | 0.02 | 1.95 | 1.12-3.40 | 0.04 | 2.14 | 1.05-4.36 | 0.33 | 1.8 | 0.56-5.80 |
CYP2D6*9 | (IM) | 0.03 | 0.53 | 0.8 | 0.40-1.60 | 0.45 | 1.18 | 0.76-1.83 | 0.62 | 1.18 | 0.62-2.23 | 0.33 | 1.52 | 0.65-3.52 |
CYP2D6*10 | (IM) | 0.02 | 0.93 | 0.96 | 0.42-2.19 | 0.61 | 1.22 | 0.57-2.59 | †n/a | †n/a | †n/a | †n/a | †n/a | †n/a |
CYP2D6*UM | (UM) | 0.08 | 0.65 | 1.57 | 0.22-11.3 | 0.45 | 0.47 | 0.07-3.34 | †n/a | †n/a | †n/a | †n/a | †n/a | †n/a |
§CYP2D6*PM Model 1 | (PM) | ‡‡N/A | 0.46 | 0.77 | 0.39-1.52 | 0.78 | 0.93 | 0.55-1.57 | 0.98 | 1.01 | 0.51-2.00 | 0.32 | 1.57 | 0.64-3.84 |
§§CYP2D6*PM Model 2 | (PM) | ‡‡N/A | 0.85 | 0.97 | 0.72-1.31 | 0.63 | 1.06 | 0.84-1.34 | 0.82 | 0.96 | 0.70-1.32 | 0.21 | 1.35 | 0.84-2.16 |
TagSNPs | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CYP2D6_01t | ¹N/A | 0.32 | 0.33 | 0.89 | 0.71-1.12 | 0.3 | 0.91 | 0.77-1.08 | 0.97 | 1 | 0.79-1.25 | 0.65 | 0.93 | 0.66-1.3 |
CYP2D6_02t | ¹N/A | 0.46 | 0.07 | 1.21 | 0.98-1.49 | 0.98 | 1 | 0.86-1.17 | 0.89 | 0.98 | 0.79-1.22 | 0.43 | 0.88 | 0.65-1.20 |
CYP2D6_03t | ¹N/A | 0.24 | 0.18 | 0.84 | 0.65-1.08 | 0.93 | 1.01 | 0.84-1.21 | 0.93 | 1.01 | 0.79-1.30 | 0.93 | 1.02 | 0.72-1.43 |
CYP2D6_04t | ¹N/A | 0.08 | 0.34 | 1.19 | 0.83-1.72 | 0.34 | 0.86 | 0.63-1.17 | 0.88 | 1.03 | 0.70-1.52 | 0.43 | 1.25 | 0.72-2.19 |
CYP2D6_05t | ¹N/A | 0.22 | 0.41 | 0.9 | 0.69-1.16 | 0.94 | 1.01 | 0.83-1.22 | 0.48 | 0.91 | 0.69-1.18 | 0.6 | 1.1 | 0.77-1.59 |