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Table 2 Characteristics of the Cowden breast cancers and the non-Cowden apocrine carcinomas

From: Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations

Tumor sample Cowden disease PTEN germline mutation status Age at diagnosis of cancer Histologic type Histologic grade Apocrine features AR ER PR ERBB2 GCDFP15 GGT1 PTEN
46 No WT 60 y IAC 2 Yes 2 0 0 0 2 2 2
96 No WT 40 y IDC 3 Yes 2 0 0 +++ 2 2 2
113 Yes c.209+5G > A 48 y IAC 1 Yes 2 0 0 0 2 2 0
116 Yes c.1007dupA p.Tyr336X 44 y IDC 2 No 2 2 2 0 0 2 0
118 Yes c.209+5G > A 35 y IAC 2 Yes 2 0 0 0 2 2 0
S89 Yes c.158_159insATAC p.val54TyrfsX10 44 y IDC 2 No 2 2 2 0 0 0 0
S243 Yes c.323T > C p.Leu108Pro 28 y IDC 2 No 2 2 2 0 0 1 0
S295 yes c.209+5G > A 44 y IAC 2 Yes 2 0 0 0 2 2 0
S362 Yes c.69dupA p.Asp24ArgfsX20 53 y DCIS low No 2 2 2 0 0 1 0
S403 Yes c.801+1delG 43 y IDC 2 No 2 2 2 0 0 0 0
S574 Yes c.491delA p.Lys164ArgfsX3 46 y IDC 1 No 2 2 2 0 0 1 0
S681 Yes c.830C > G p.Thr277Arg 27 y IDC 3 Yes 2 2 1 + 1 1 0
S712 Yes c.592delA p.Met198X 41 y MPC 2 Yes 2 2 0 nd 0 1 0
S730 Yes c.493G > A p.Gly165Arg 59 y ILC 2 No 2 2 2 + 2 0 0
S732 Yes c.510T > G p.Ser170Arg 46 y IDC 2 Yes 2 2 2 0 1 1 1
S891 yes c.209+5G > A 35 y IAC 2 Yes 2 0 0 ++ 2 2 2
S912 Yes c.632_633delGC p.Cys211X 34 y IDC 2 No 2 2 2 0 1 1 0
  1. IHC status excepted for ERBB2 (0 to +++): 0 = negative; 1 = positive up to 10% of cells; 2 = positive above 10% of cells. DCIS, ductal carcinoma in situ; IAC, invasive apocrine carcinoma; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; MPC, micro papillary carcinoma; nd, not determined; WT, wild type.