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Table 2 Characteristics of the Cowden breast cancers and the non-Cowden apocrine carcinomas

From: Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations

Tumor sample

Cowden disease

PTEN germline mutation status

Age at diagnosis of cancer

Histologic type

Histologic grade

Apocrine features

AR

ER

PR

ERBB2

GCDFP15

GGT1

PTEN

46

No

WT

60 y

IAC

2

Yes

2

0

0

0

2

2

2

96

No

WT

40 y

IDC

3

Yes

2

0

0

+++

2

2

2

113

Yes

c.209+5G > A

48 y

IAC

1

Yes

2

0

0

0

2

2

0

116

Yes

c.1007dupA p.Tyr336X

44 y

IDC

2

No

2

2

2

0

0

2

0

118

Yes

c.209+5G > A

35 y

IAC

2

Yes

2

0

0

0

2

2

0

S89

Yes

c.158_159insATAC p.val54TyrfsX10

44 y

IDC

2

No

2

2

2

0

0

0

0

S243

Yes

c.323T > C p.Leu108Pro

28 y

IDC

2

No

2

2

2

0

0

1

0

S295

yes

c.209+5G > A

44 y

IAC

2

Yes

2

0

0

0

2

2

0

S362

Yes

c.69dupA p.Asp24ArgfsX20

53 y

DCIS

low

No

2

2

2

0

0

1

0

S403

Yes

c.801+1delG

43 y

IDC

2

No

2

2

2

0

0

0

0

S574

Yes

c.491delA p.Lys164ArgfsX3

46 y

IDC

1

No

2

2

2

0

0

1

0

S681

Yes

c.830C > G p.Thr277Arg

27 y

IDC

3

Yes

2

2

1

+

1

1

0

S712

Yes

c.592delA p.Met198X

41 y

MPC

2

Yes

2

2

0

nd

0

1

0

S730

Yes

c.493G > A p.Gly165Arg

59 y

ILC

2

No

2

2

2

+

2

0

0

S732

Yes

c.510T > G p.Ser170Arg

46 y

IDC

2

Yes

2

2

2

0

1

1

1

S891

yes

c.209+5G > A

35 y

IAC

2

Yes

2

0

0

++

2

2

2

S912

Yes

c.632_633delGC p.Cys211X

34 y

IDC

2

No

2

2

2

0

1

1

0

  1. IHC status excepted for ERBB2 (0 to +++): 0 = negative; 1 = positive up to 10% of cells; 2 = positive above 10% of cells. DCIS, ductal carcinoma in situ; IAC, invasive apocrine carcinoma; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; MPC, micro papillary carcinoma; nd, not determined; WT, wild type.