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Table 1 Gene ontology enrichment for the Cowden signature and comparison with other signatures

From: Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations

Gene Ontology interrogation P-value
Oxidoreductase activity 3 × 10-11
Lipid metabolic process 1 × 10-10
Cellular lipid metabolic process 4 × 10-7
Carboxylic acid metabolic process 1 × 10-5
Organic acid metabolic process 1 × 10-5
KEGG pathway database interrogation  
PPAR signaling pathway 3 × 10-6
Bile acid biosynthesis 6 × 10-5
Androgen and estrogen metabolism 1 × 10-4
Arachidonic acid metabolism 2 × 10-4
Metabolism of xenobiotics by cytochrome P450 4 × 10-4
MSig database interrogation  
Molecular apocrine signature (Farmer et al.) 6 × 10-50
Genes upregulated by androgen in neoplastic prostate epithelium (Nelson et al.) 1 × 10-10
Genes annotated in NetAffx as androgen related (NetAffx) 2 × 10-8
Genes downregulated in AIDS-related primary effusion lymphoma (PEL) cells compared to normal B cells and other tumor subtypes. (Klein et al.) 2 × 10-4
Genes downregulated by telomerase (Smith et al.) 4 × 10-4
Downregulated in mature, differentiated adipocytes following treatment with TNFalpha (Ruan et al.) 4 × 10-4