Table 1 Gene ontology enrichment for the Cowden signature and comparison with other signatures
Gene Ontology interrogation | P-value |
|---|---|
Oxidoreductase activity | 3 × 10-11 |
Lipid metabolic process | 1 × 10-10 |
Cellular lipid metabolic process | 4 × 10-7 |
Carboxylic acid metabolic process | 1 × 10-5 |
Organic acid metabolic process | 1 × 10-5 |
KEGG pathway database interrogation | |
PPAR signaling pathway | 3 × 10-6 |
Bile acid biosynthesis | 6 × 10-5 |
Androgen and estrogen metabolism | 1 × 10-4 |
Arachidonic acid metabolism | 2 × 10-4 |
Metabolism of xenobiotics by cytochrome P450 | 4 × 10-4 |
MSig database interrogation | |
Molecular apocrine signature (Farmer et al.) | 6 × 10-50 |
Genes upregulated by androgen in neoplastic prostate epithelium (Nelson et al.) | 1 × 10-10 |
Genes annotated in NetAffx as androgen related (NetAffx) | 2 × 10-8 |
Genes downregulated in AIDS-related primary effusion lymphoma (PEL) cells compared to normal B cells and other tumor subtypes. (Klein et al.) | 2 × 10-4 |
Genes downregulated by telomerase (Smith et al.) | 4 × 10-4 |
Downregulated in mature, differentiated adipocytes following treatment with TNFalpha (Ruan et al.) | 4 × 10-4 |