Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro

Table 3 Cox regression analysis of overall survival in the entire patient cohort^a

	Entire cohort (n= 281)
	Univariate			Multivariate*
Prognostic factor	HR	(95% CI)	P value	HR	(95% CI)	P value
Cytoplasmic Msx2 (high vs. low, ref)	0.69	0.49-0.97	0.031	0.58	0.36-0.93	0.023
Age (continuous)	1.06	1.05-1.07	<0.001	1.05	1.03-1.07	<0.001
Tumour size (continuous)	1.01	1.00-1.01	<0.001	1.01	1.00-1.02	0.006
Tumour grade (3 vs. 0-2, ref)	2.09	1.63-2.67	<0.001	1.78	1.06-2.99	0.028
Nodal status (pos vs. neg, ref)	3.18	2.43-4.16	<0.001	3.06	1.95-4.80	<0.001
ER (pos vs. neg, ref)	0.73	0.52-1.02	0.062	0.92	0.38-2.21	0.855
PR (pos vs. neg, ref)	0.61	0.46-0.81	0.001	0.68	0.41-1.13	0.140
Her2 (3 vs. 0-2, ref)	0.77	0.49-1.22	0.270	0.63	0.23-1.69	0.355
Ki-67 (>10% vs. <10%, ref)	1.31	1.01-1.71	0.044	1.15	0.67-1.97	0.610

^aMsx2, muscle segment homeobox 2; ER, estrogen receptor; PR, progesterone receptor; Her2, human epidermal growth factor 2; Ki67, proliferation-related Ki-67 antigen. *Adjusted for all other variables in the table; ref, referent group.

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