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Table 3 Cox regression analysis of overall survival in the entire patient cohorta

From: Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro

  Entire cohort (n= 281)
  Univariate Multivariate*
Prognostic factor HR (95% CI) P value HR (95% CI) P value
Cytoplasmic Msx2 (high vs. low, ref) 0.69 0.49-0.97 0.031 0.58 0.36-0.93 0.023
Age (continuous) 1.06 1.05-1.07 <0.001 1.05 1.03-1.07 <0.001
Tumour size (continuous) 1.01 1.00-1.01 <0.001 1.01 1.00-1.02 0.006
Tumour grade (3 vs. 0-2, ref) 2.09 1.63-2.67 <0.001 1.78 1.06-2.99 0.028
Nodal status (pos vs. neg, ref) 3.18 2.43-4.16 <0.001 3.06 1.95-4.80 <0.001
ER (pos vs. neg, ref) 0.73 0.52-1.02 0.062 0.92 0.38-2.21 0.855
PR (pos vs. neg, ref) 0.61 0.46-0.81 0.001 0.68 0.41-1.13 0.140
Her2 (3 vs. 0-2, ref) 0.77 0.49-1.22 0.270 0.63 0.23-1.69 0.355
Ki-67 (>10% vs. <10%, ref) 1.31 1.01-1.71 0.044 1.15 0.67-1.97 0.610
  1. aMsx2, muscle segment homeobox 2; ER, estrogen receptor; PR, progesterone receptor; Her2, human epidermal growth factor 2; Ki67, proliferation-related Ki-67 antigen. *Adjusted for all other variables in the table; ref, referent group.