Variable | Cytoplasmic Msx2 | Nuclear Msx2 | ||||
---|---|---|---|---|---|---|
Low Msx2 (n= 168) | High Msx2 (n= 113) | P value | Low Msx2 (n= 122) | High Msx2 (n= 159) | P value | |
Age | ||||||
Median (range) | 66 (35-96) | 64 (36-89) | 65 (35-96) | 65.5 (35-91) | ||
≤50 | 23 (13.7) | 14 (12.4) | 0.752 | 19 (15.6) | 18 (11.3) | 0.296 |
>50 | 145 (86.3) | 99 (87.6) | 103 (84.4) | 141 (88.7) | ||
Tumour size | ||||||
Median (range) | 18 (0-100) | 16 (1-100) | 19 (0-100) | 15.5 (1-100) | ||
≤2 cm | 105 (62.5) | 75 (66.4) | 0.507 | 74 (60.7) | 106 (66.7) | 0.298 |
>2 cm | 63 (37.5) | 38 (33.6) | 48 (39.3) | 53 (33.3) | ||
Histological type | ||||||
Ductal | 115 (75.7) | 75 (69.4) | 0.157* | 80 (72.7) | 110 (73.3) | 0.715* |
Lobular | 19 (12.5) | 22 (20.4) | 19 (17.3) | 22 (14.7) | ||
Tubular | 9 (5.9) | 8 (7.4) | 5 (4.5) | 12 (8) | ||
Medullary | 5 3.3) | 0 | 3 (2.7) | 2 (1.3) | ||
Mucinous | 4 (2.6) | 3 (2.8) | 3 (2.7) | 4 (2.7) | ||
Unknown | 16 | 5 | 12 | 9 | ||
Nodal status | ||||||
Negative | 89 (59.3) | 69 (69) | 0.121 | 66 (61.1) | 92 (64.8) | 0.550 |
Positive | 61 (40.7) | 31 (31) | 42 (38.9) | 50 (35.2) | ||
Unknown | 18 | 13 | 14 | 17 | ||
Tumour grade | ||||||
I | 34 (20.4) | 35 (31) | 0.012 | 20 (16.4) | 49 (31) | 0.015 |
II | 66 (39.5) | 51 (45.1) | 54 (44.3) | 63 (39.9) | ||
III | 67 (40.1) | 27 (23.9) | 48 (39.3) | 46 (29.1) | ||
Unknown | 1 | 0 | 0 | 1 | ||
ER status | ||||||
Negative | 23 (14.1) | 16 (14.7) | 0.896 | 23 (19.3) | 16 (10.5) | 0.038 |
Positive | 140 (85.9) | 93 (85.3) | 96 (80.7) | 137 (89.5) | ||
Unknown | 5 | 4 | 3 | 6 | ||
PR status | ||||||
Negative | 47 (36.4) | 38 (40.9) | 0.503 | 41 (40.6) | 44 (36.4) | 0.518 |
Positive | 82 (63.6) | 55 (59.1) | 60 (59.4) | 77 (63.6) | ||
Unknown | 39 | 20 | 21 | 38 | ||
Ki 67 (%) | ||||||
<10% | 56 (34.1) | 52 (48.6) | 0.018 | 35 (30.2) | 73 (47.1) | 0.005 |
>10% | 108 (65.9) | 55 (51.4) | 81 (69.8) | 82 (52.9) | ||
Unknown | 4 | 6 | 6 | 4 | ||
VEGF (%) | ||||||
Low (0-2+) | 92 (78) | 77 (86.5) | 0.116 | 76 (83.5) | 93 (80.2) | 0.537 |
High (3) | 26 (22) | 12 (13.5) | 15 (16.5) | 23 (19.8) | ||
Unknown | 50 | 24 | 31 | 43 | ||
Her2 (%) | ||||||
Low (0-2) | 141 (89.2) | 95 (92.2) | 0.422 | 100 (89.3) | 136 (91.3) | 0.589 |
High (3) | 17 (10.8) | 8 (7.8) | 12 (10.7) | 13 (8.7) | ||
Unknown | 10 | 10 | 10 | 10 | ||
Cyclin D1 (%) | ||||||
Low (0-1%) | 20 (12.5) | 17 (15.7) | 0.706 | 21 (17.9) | 16 (10.6) | 0.037 |
Med (2-25%) | 109 (68.1) | 69 (63.9) | 80 (68.4) | 98 (64.9) | ||
High (>25%) | 31 (19.4) | 22 (20.4) | 16 (13.7) | 37 (24.5) | ||
Unknown | 8 | 5 | 5 | 8 |