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Table 2 Association of cytoplasmic and nuclear Msx2 with clinicopathological parameters in 281 tumours on a TMAa

From: Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro

Variable Cytoplasmic Msx2 Nuclear Msx2
  Low Msx2
(n= 168)
High Msx2
(n= 113)
P value Low Msx2
(n= 122)
High Msx2
(n= 159)
P value
Age       
   Median (range) 66 (35-96) 64 (36-89)   65 (35-96) 65.5 (35-91)  
   ≤50 23 (13.7) 14 (12.4) 0.752 19 (15.6) 18 (11.3) 0.296
   >50 145 (86.3) 99 (87.6)   103 (84.4) 141 (88.7)  
Tumour size       
   Median (range) 18 (0-100) 16 (1-100)   19 (0-100) 15.5 (1-100)  
   ≤2 cm 105 (62.5) 75 (66.4) 0.507 74 (60.7) 106 (66.7) 0.298
   >2 cm 63 (37.5) 38 (33.6)   48 (39.3) 53 (33.3)  
Histological type       
   Ductal 115 (75.7) 75 (69.4) 0.157* 80 (72.7) 110 (73.3) 0.715*
   Lobular 19 (12.5) 22 (20.4)   19 (17.3) 22 (14.7)  
   Tubular 9 (5.9) 8 (7.4)   5 (4.5) 12 (8)  
   Medullary 5 3.3) 0   3 (2.7) 2 (1.3)  
   Mucinous 4 (2.6) 3 (2.8)   3 (2.7) 4 (2.7)  
   Unknown 16 5   12 9  
Nodal status       
   Negative 89 (59.3) 69 (69) 0.121 66 (61.1) 92 (64.8) 0.550
   Positive 61 (40.7) 31 (31)   42 (38.9) 50 (35.2)  
   Unknown 18 13   14 17  
Tumour grade       
   I 34 (20.4) 35 (31) 0.012 20 (16.4) 49 (31) 0.015
   II 66 (39.5) 51 (45.1)   54 (44.3) 63 (39.9)  
   III 67 (40.1) 27 (23.9)   48 (39.3) 46 (29.1)  
   Unknown 1 0   0 1  
ER status       
   Negative 23 (14.1) 16 (14.7) 0.896 23 (19.3) 16 (10.5) 0.038
   Positive 140 (85.9) 93 (85.3)   96 (80.7) 137 (89.5)  
   Unknown 5 4   3 6  
PR status       
   Negative 47 (36.4) 38 (40.9) 0.503 41 (40.6) 44 (36.4) 0.518
   Positive 82 (63.6) 55 (59.1)   60 (59.4) 77 (63.6)  
   Unknown 39 20   21 38  
Ki 67 (%)       
   <10% 56 (34.1) 52 (48.6) 0.018 35 (30.2) 73 (47.1) 0.005
   >10% 108 (65.9) 55 (51.4)   81 (69.8) 82 (52.9)  
   Unknown 4 6   6 4  
VEGF (%)       
   Low (0-2+) 92 (78) 77 (86.5) 0.116 76 (83.5) 93 (80.2) 0.537
   High (3) 26 (22) 12 (13.5)   15 (16.5) 23 (19.8)  
   Unknown 50 24   31 43  
Her2 (%)       
   Low (0-2) 141 (89.2) 95 (92.2) 0.422 100 (89.3) 136 (91.3) 0.589
   High (3) 17 (10.8) 8 (7.8)   12 (10.7) 13 (8.7)  
   Unknown 10 10   10 10  
Cyclin D1 (%)       
   Low (0-1%) 20 (12.5) 17 (15.7) 0.706 21 (17.9) 16 (10.6) 0.037
   Med (2-25%) 109 (68.1) 69 (63.9)   80 (68.4) 98 (64.9)  
   High (>25%) 31 (19.4) 22 (20.4)   16 (13.7) 37 (24.5)  
   Unknown 8 5   5 8  
  1. aMsx2, muscle segment homeobox 2; ER, estrogen receptor; PR, progesterone receptor; Ki67, proliferation-related Ki-67 antigen; VEGF, vascular endothelial growth factor; Her2, human epidermal growth factor 2; *Fisher's exact test;, otherwise, χ2 test.