Distribution of additional domain-positive and additional domain-negative breast carcinomas in relation to patient age. Number of carcinomas positive or negative for both additional domain AD (1) and AD2. Box contains cases within the lower and upper quartiles, and the line indicates median age. The whiskers connect the youngest and oldest patients that are not outliers; o, outliers; *, extreme values, defined as more than three box-lengths from the box. TNC, tenascin-C.