Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer

Breast Cancer Research

Table 4 Association of other members and effectors of the thioredoxin pathway with metastasis-free survival

	Prognostic factor	Pvalue	HR	95% CI
Mainz cohort (n=200)	TXN RNA expression	0.001	3.029	1.599 to 5.738
	RRM2 RNA expression	0.001	1.598	1.205 to 2.120
	PRDX2 RNA expression	0.066	1.950	0.957 to 3.975
	HIF1A RNA expression	0.568	0.870	0.540 to 1.403
	VEGFA RNA expression	0.485	1.206	0.713 to 2.042
	PTEN RNA expression	0.313	0.774	0.470 to 1.273
Rotterdam cohort (n=286)	TXN RNA expression	0.067	1.428	0.976 to 2.091
	RRM2 RNA expression	< 0.001	1.440	1.181 to 1.756
	PRDX2 RNA expression	0.234	0.767	0.496 to 1.187
	HIF1A RNA expression	0.003	1.545	1.160 to 2.058
	VEGFA RNA expression	0.907	0.982	0.724 to 1.332
	PTEN RNA expression	0.339	0.851	0.612 to 1.184
Transbig cohort (n=302)	TXN RNA expression	0.069	1.411	0.974 to 2.043
	RRM2 RNA expression	0.003	1.354	1.107 to 1.655
	PRDX2 RNA expression	0.687	1.129	0.627 to 2.033
	HIF1A RNA expression	0.024	1.464	1.052 to 2.038
	VEGFA RNA expression	0.045	1.393	1.007 to 1.926
	PTEN RNA expression	0.197	0.802	0.573 to 1.121
Combined cohort (n=788)	TXN RNA expression	< 0.001	1.755	1.436 to 2.145
	RRM2 RNA expression	< 0.001	1.469	1.298 to 1.663
	PRDX2 RNA expression	0.004	1.423	1.120 to 1.807
	HIF1A RNA expression	< 0.001	1.440	1.184 to 1.750
	VEGFA RNA expression	0.033	1.239	1.018 to 1.508
	PTEN RNA expression	0.243	0.885	0.720 to 1.087

Association of TXN, RRM2, PRDX2, HIF1A, VEGF and PTEN RNA expression with metastasis-free survival in patients with node-negative breast cancer in the univariate Cox analysis. In the Mainz cohort, TXN and RRM2 RNA expressions are associated with worse metastasis-free survival. In the Rotterdam cohort, RRM2 and HIF1A are associated with metastasis-free survival. In the Transbig cohort, significant associations were found for RRM2, HIF1A and VEGFA. In the combined cohort of 788 patients, a significant association of all factors with metastasis-free survival, except PTEN, was obtained. HR, hazard ratio; CI, confidence interval.

ISSN: 1465-542X