Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer

Breast Cancer Research

Table 3 Multivariate analysis of the association between TXNRD1 and TXNIP RNA expression with metastasis-free survival

Prognostic factor	Pvalue	HR	95% CI
Age (< 50 years vs. ≥50 years)	0.511	1.176	0.725 to 1.910
pT stage (≤2 cm vs. >2 cm)	< 0.001	3.526	1.866 to 6.661
Histological grade (grade III vs. grades I and II)	0.223	0.708	0.406 to 1.234
Hormone receptor^a, ER or PR (negative vs. positive)	0.865	0.951	0.529 to 1.707
ERBB2 status (positive vs. negative)	0.449	1.276	0.679 to 2.399
TXNRD1 RNA expression	0.162	1.445	0.862 to 2.420
TXNIP RNA expression	0.037	0.654	0.439 to 0.974

The analysis was carried out in patients with node-negative breast cancer in the univariate Cox analysis (Transbig cohort, n = 302). HR, hazard ratio; CI, confidence interval; TXNRD1, thioredoxin reductase 1; TXNIP, thioredoxin interacting protein. ^aThe hormone receptor status (HR) is positive as soon as either the estrogen receptor (ER) status or the progesterone receptor (PR) status is positive.

ISSN: 1465-542X