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Table 3 Patient and tumor characteristics for the six genomic subtypes

From: Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

  Basal-complex n(%) 17q12 n(%) Luminal-complex n(%) Luminal-simple n(%) Amplifier n(%) Mixed n(%)
Group size 67 51 105 46 52 38
Hereditary status       
   BRCA1-mutated 17 (25) 0 1 (1) 0 2 (4) 2 (5)
   BRCA2-mutated 5 (7) 1 (2) 25 (24) 0 0 1 (3)
   Familial 15 (22) 19 (37) 38 (36) 23 (50) 29 (56) 8 (21)
   Sporadic 30 (45) 31 (61) 41 (39) 23 (50) 21 (40) 27 (71)
Clinical parameters       
   ER+ 7 (10) 19 (37) 91 (87) 44 (96) 40 (77) 26 (68)
   ER- 56 (84) 29 (57) 11 (10) 2 (4) 10 (19) 11 (29)
   LN+ 19 (28) 25 (49) 42 (40) 12 (26) 20 (38) 19 (50)
   LN- 43 (64) 19 (37) 50 (48) 32 (70) 28 (54) 18 (47)
Mean tumor size (mm ± SD) 27 ± 12 31 ± 21 26 ± 17 21 ± 10 25 ± 13 25 ± 11
   Histologic grade 1 1 (1) 1 (2) 5 (5) 9 (20) 8 (15) 2 (5)
   Histologic grade 2 5 (7) 14 (27) 31 (30) 21 (46) 19 (37) 10 (26)
   Histologic grade 3 42 (63) 19 (37) 26 (25) 4 (9) 9 (17) 6 (16)
Molecular subtypes by Hu et al. [4]       
   Basal-like 56 (84) 5 (10) 4 (4) 0 8 (15) 6 (16)
   HER2-enriched 0 30 (59) 3 (3) 0 0 1 (3)
   Luminal B 1 (1) 3 (6) 48 (46) 1 (2) 12 (23) 5 (13)
   Luminal A 1 (1) 6 (12) 31 (30) 33 (72) 12 (23) 12 (32)
   Normal-like 3 (4) 6 (12) 3 (3) 6 (13) 10 (19) 6 (16)
   Unclassified 6 (9) 1 (2) 16 (15) 6 (13) 10 (19) 8 (21)
FGA (mean %)       
   Overall FGA (%) 53 26 37 19 31 29
   Gain FGA (%) 18 12 15 9 15 12
   Loss FGA (%) 34 14 22 10 16 18
  1. ER, Estrogen receptor; FGA, fraction of the genome altered; LN, lymph node.