High-level amplifications in breast cancer (BC). (a) Coamplification patterns in BC. For each amplification (vertical axis), the fraction of samples with a coamplification (horizontal axis) is indicated in each box. Coamplification fractions smaller than 20% are excluded: for example, 30% of all 12q15-amplified samples also have 8p12 amplification, whereas the fraction of 8p12-amplified samples with 12q15 amplification is < 0.2 and is not displayed. (b) Overview of the coamplification pattern in chromosomes 8p12, 11q13, and 12q15. Amplification pattern is also evident on a gene-expression level, where a number of genes show a significant relation to gene-dosage effects.