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Table 1 Paclitaxel sensitivity index for indicated genes from shRNA screen

From: RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells

 

> 3 clones mean SI > 0.078

  

< 3 clones mean SI > 0.150

Gene

shRNAs

Mean SI

95% CI

Genomic dereg*

Gene

shRNAs

Mean SI

Genomic dereg*

YWHAZ

6

0.193

0.154 to 0.242

amp/OE

PCK1

1

0.461

amp/OE

RPS6KB1

4

0.186

0.135 to 0.242

amp/OE

SREBF2

1

0.391

amp/OE

COG2

5

0.186

0.110 to 0.265

amp/OE

SRC

1

0.276

amp/OE

PTK2

5

0.184

0.121 to 0.287

amp/OE

FNTA

1

0.263

amp/OE

PPM1D

4

0.179

0.120 to 0.241

amp/OE

BCL2L1

1

0.247

amp/OE

SKP1A

6

0.166

0.075 to 0.259

amp/OE

COMMD1

3

0.220

amp/OE

MARK1

5

0.157

0.006 to 0.345

amp/OE

COG8

1

0.214

amp/OE

NFYB

4

0.148

0.085 to 0.186

amp/OE

FRAP1

1

0.212

NA

RBBP4

4

0.139

0.080 to 0.198

amp/OE

ERBB2

1

0.180

amp/OE

IL10

4

0.136

0.081 to 0.205

amp/OE

IQGAP1

3

0.176

amp/OE

EGFR

4

0.136

0.087 to 0.378

amp/OE

PHB

3

0.159

amp/OE

SP1

5

0.130

0.080 to 0.138

amp/OE

NDUFS6

1

0.159

amp/OE

STX16

4

0.107

0.053 to 0.175

amp/OE

COG1

1

0.159

amp/OE

PTPN7

4

0.095

0.019 to 0.170

amp/OE

PRPF4B

3

0.156

amp/OE

SENP1

5

0.095

0.022 to 0.168

amp/OE

FADD

3

0.156

amp/OE

CENPF

4

0.085

0.030 to 0.140

amp/OE

ERK1

1

0.154

amp/OE

IGF1

4

0.078

0.016 to 0.137

amp/OE

TGFB1

1

0.153

amp/OE

     

TUBG1

3

0.152

amp/OE

CASP3

(control)

5

-0.042

-0.061 to -0.021

del/UE

IKBKB

2

0.151

amp/OE

  1. *as determined by DNA copy number and gene expression analysis by Neve et al.
  2. SI, sensitivity index; CI, confidence interval
  3. amp/OE, amplification/overexpressed; del/UE, deletion/underexpressed
  4. NA, not available
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Breast Cancer Research

ISSN: 1465-542X

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