Table 1 Prognostic capacity of the sets of dynamically changing genes in patients treated with tamoxifen
Study/dataset | Tamoxifen-treated datasets | Untreated datasets | ||||
|---|---|---|---|---|---|---|
| Â | Zhang and colleagues [11] | Loi and colleagues [34] | Sotiriou and colleagues [35] | Wang and colleagues [37] | Desmedt and colleagues [38] | |
NCBI GEO dataset [20] | GSE12093 | GSE6532 | GSE2990 | GSE2034 | GSE7390 | |
Affymetrix GeneChip | U133A | U133A | U133 plus2 | U133A | U133A | U133A |
No tumors (All ER+ and TAM-treated) | 136 | 119 | 87 | 62 | 209 | 134 |
Tumor grade (1/2/3/NA) | 8/43/30/55 | 1/94/4/20 | 17/37/16/17 | 32/0/27/3 | NA | 29/68/35/2 |
Age (median) | 64* | 65 | 63 | 66 | 52 | 47 |
Follow up (median) | 7.1 | 5.2 | 11.4 | 4.9 | 7.2 | 10.4 |
Endpoint | DFS | RFS | RFS | RFS | RFS | DFS |
All dynamic genes (sets 1 to 6) | P= 0.7 | P= 0.2 | P = 0.0006 | P= 0.1 | P = 0.005 | P= 0.6 |
Set 1 (early/transient) | P = 0.00005 | P = 0.0002 | P = 0.0002 | P = 0.002 | P = 0.002 | P = 0.04 |
Set 2 (early transient) | P= 0.4 | P= 0.3 | P= 0.5 | P = 0.03 | P = 0.03 | P= 0.2 |
Set 3 (variable) | P= 0.8 | P= 0.7 | P= 0.2 | P= 0.6 | P = 0.0005 | P= 0.1 |
Set 4 (variable) | P= 0.5 | P= 0.2 | P = 0.008 | P= 0.6 | P= 0.7 | P= 0.3 |
Set 5 (continuous/late) | P= 0.1 | P= 0.2 | P= 0.1 | P= 0.5 | P= 0.1 | P= 0.2 |