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Table 2 Average relative methylation levels of genes previously associated with ER and HER2 status

From: Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns

CpG site Basal-like
(n = 43)
Luminal or HER2-enriched
(n = 95)
P-value1 ER-negative
(n = 61)
ER-positive
(n = 113)
P-value1
RASSF1_E116_F -0.37 0.16 2 × 10-11 -0.22 0.13 2 × 10-7
RASSF1_P244_F -0.32 0.16 2 × 10-11 -0.19 0.12 3 × 10-7
GSTP1_E322_R -0.24 0.07 2 × 10-5 -0.02 0.03 0.4
GSTP1_P74_F -0.11 0.03 0.02 -0.04 0.03 0.2
GSTP1_seq_38_S153_R -0.10 0.05 6 × 10-3 -0.01 0.02 0.7
APC_P14_F -0.38 0.11 2 × 10-8 -0.19 0.11 5 × 10-5
APC_P280_R -0.13 0.07 2 × 10-4 -0.10 0.05 5 × 10-4
  1. 1Wilcoxon test.
  2. ER, oestrogen receptor; HER2, human epidermal growth factor receptor 2