Table 2 Average relative methylation levels of genes previously associated with ER and HER2 status
From: Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
CpG site | Basal-like (n = 43) | Luminal or HER2-enriched (n = 95) | P-value1 | ER-negative (n = 61) | ER-positive (n = 113) | P-value1 |
|---|---|---|---|---|---|---|
RASSF1_E116_F | -0.37 | 0.16 | 2 × 10-11 | -0.22 | 0.13 | 2 × 10-7 |
RASSF1_P244_F | -0.32 | 0.16 | 2 × 10-11 | -0.19 | 0.12 | 3 × 10-7 |
GSTP1_E322_R | -0.24 | 0.07 | 2 × 10-5 | -0.02 | 0.03 | 0.4 |
GSTP1_P74_F | -0.11 | 0.03 | 0.02 | -0.04 | 0.03 | 0.2 |
GSTP1_seq_38_S153_R | -0.10 | 0.05 | 6 × 10-3 | -0.01 | 0.02 | 0.7 |
APC_P14_F | -0.38 | 0.11 | 2 × 10-8 | -0.19 | 0.11 | 5 × 10-5 |
APC_P280_R | -0.13 | 0.07 | 2 × 10-4 | -0.10 | 0.05 | 5 × 10-4 |