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Table 1 Patient and tumour characteristics for the 189 patients

From: Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns

Characteristic Basal-like (n = 43) (%) LumA (n = 46) (%) LumB (n = 35) (%) HER2-enriched (n = 14) (%) Normal-like (n = 17) (%) Non-classified (n = 24) (%) Non-GEX (n = 10) (%) Total (n = 189) (%)
Family status         
   BRCA1 9 (21) 1 (2) 1 (3) 0 1 (6) 0 3 (43) 15 (8)
   BRCA2 1 (2) 1 (2) 7 (20) 0 0 0 4 (57) 13 (7)
   Familial 7 (16) 10 (22) 11 (31) 3 (21) 5 (29) 7 (29) 0 43 (23)
   Sporadic 26 (60) 34 (74) 16 (46) 11 (79) 11 (65) 17 (71) 0 115 (62)
   Unknown 0 0 0 0 0 0 3 3
ER status         
   Positive 2 (5) 44 (96) 31 (91) 5 (36) 10 (67) 20 (83) 1 (100) 113 (65)
   Negative 38 (95) 2 (4) 3 (9) 9 (64) 5 (33) 4 (17) 0 61 (35)
   Unknown 3 0 1 0 2 0 9 15
PgR status         
   Positive 2 (5) 44 (96) 28 (82) 5 (36) 8 (53) 20 (83) 1 (100) 108 (62)
   Negative 38 (95) 2 (4) 6 (18) 9 (64) 7 (47) 4 (17) 0 66 (38)
   Unknown 3 0 1 0 2 0 9 15
Histological grade         
   Grade 1 0 9 (28) 3 (10) 0 1 (8) 5 (23) 0 18 (12)
   Grade 2 2 (5) 20 (63) 10 (34) 3 (27) 8 (62) 5 (23) 0 48 (32)
   Grade 3 39 (95) 3 (9) 16 (55) 8 (73) 4 (31) 12 (54) 0 82 (55)
   Unknown 2 14 6 3 4 2 10 41
Node status         
   Negative 28 (68) 36 (80) 17 (61) 11 (85) 9 (56) 16 (70) 0 117 (70)
   Positive 13 (32) 9 (20) 11 (39) 2 (15) 7 (44) 7 (30) 0 49 (30)
   Unknown 2 1 7 1 1 1 10 23
Age (median) 46 49.5 48 45.5 49 48.5 na 48
  1. Cases for which data are unknown are excluded from total when calculating percentage.
  2. ER, oestrogen receptor; GEX, gene expression; HER2, human epidermal growth factor receptor 2; lumA, luminal A; lumB, luminal B; na, not available; PgR, progesterone receptor.