Table 1 Patient and tumour characteristics for the 189 patients
From: Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Characteristic | Basal-like (n = 43) (%) | LumA (n = 46) (%) | LumB (n = 35) (%) | HER2-enriched (n = 14) (%) | Normal-like (n = 17) (%) | Non-classified (n = 24) (%) | Non-GEX (n = 10) (%) | Total (n = 189) (%) |
|---|---|---|---|---|---|---|---|---|
Family status | ||||||||
BRCA1 | 9 (21) | 1 (2) | 1 (3) | 0 | 1 (6) | 0 | 3 (43) | 15 (8) |
BRCA2 | 1 (2) | 1 (2) | 7 (20) | 0 | 0 | 0 | 4 (57) | 13 (7) |
Familial | 7 (16) | 10 (22) | 11 (31) | 3 (21) | 5 (29) | 7 (29) | 0 | 43 (23) |
Sporadic | 26 (60) | 34 (74) | 16 (46) | 11 (79) | 11 (65) | 17 (71) | 0 | 115 (62) |
Unknown | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 |
ER status | ||||||||
Positive | 2 (5) | 44 (96) | 31 (91) | 5 (36) | 10 (67) | 20 (83) | 1 (100) | 113 (65) |
Negative | 38 (95) | 2 (4) | 3 (9) | 9 (64) | 5 (33) | 4 (17) | 0 | 61 (35) |
Unknown | 3 | 0 | 1 | 0 | 2 | 0 | 9 | 15 |
PgR status | ||||||||
Positive | 2 (5) | 44 (96) | 28 (82) | 5 (36) | 8 (53) | 20 (83) | 1 (100) | 108 (62) |
Negative | 38 (95) | 2 (4) | 6 (18) | 9 (64) | 7 (47) | 4 (17) | 0 | 66 (38) |
Unknown | 3 | 0 | 1 | 0 | 2 | 0 | 9 | 15 |
Histological grade | ||||||||
Grade 1 | 0 | 9 (28) | 3 (10) | 0 | 1 (8) | 5 (23) | 0 | 18 (12) |
Grade 2 | 2 (5) | 20 (63) | 10 (34) | 3 (27) | 8 (62) | 5 (23) | 0 | 48 (32) |
Grade 3 | 39 (95) | 3 (9) | 16 (55) | 8 (73) | 4 (31) | 12 (54) | 0 | 82 (55) |
Unknown | 2 | 14 | 6 | 3 | 4 | 2 | 10 | 41 |
Node status | ||||||||
Negative | 28 (68) | 36 (80) | 17 (61) | 11 (85) | 9 (56) | 16 (70) | 0 | 117 (70) |
Positive | 13 (32) | 9 (20) | 11 (39) | 2 (15) | 7 (44) | 7 (30) | 0 | 49 (30) |
Unknown | 2 | 1 | 7 | 1 | 1 | 1 | 10 | 23 |
Age (median) | 46 | 49.5 | 48 | 45.5 | 49 | 48.5 | na | 48 |