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Table 4 Breast cancer incidence in pre-, peri/postmenopausal and all women in relation to serum TSH levels

From: Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women

Group TSH
(quartile)
Individuals
(n)
Breast cancer
cases
(n)
Person-years Incidence/100,000 All cases Cases >3 years following
Baseline examination
       RR
(CI: 95%)
RR**
(CI: 95%)
RR
(CI: 95%)
RR**
(CI: 95%)
All 1 647 40 11,764 340 1.00 1.00 1.00 1.00
  2 528 42 9,517 441 1.05 (0.70 to 1.58) 1.07 (0.71 to 1.62) 1.28 (0.81 to 2.01) 1.26 (0.80 to 1.97)
  3 793 55 15,829 347 0.93 (0.62 to 1.41) 0.94 (0.62 to 1.42) 1.20 (0.77 to 1.87) 1.19 (0.76 to 1.85)
  4 710 36 14,521 248 0.87 (0.55 to 1.37) 0.80 (0.50 to 1.27) 0.95 (0.57 to 1.57) 1.03 (0.62 to 1.69)
  P-trend      0.46 0.29 0.82 0.94
Premenopausal 1 155 10 3,170 315 1.00 1.00 1.00 1.00
  2 221 18 4,669 386 1.48 (0.76 to 2.90) 1.38 (0.69 to 2.77) 1.91(0.90 to 4.08) 2.02 (0.97 to 4.23)
  3 329 28 6,869 408 0.95 (0.48 to 1.87) 0.94 (0.47 to 1.87) 1.31(0.62 to 2.79) 1.30 (0.62 to 2.72)
  4 194 7 4,213 166 0.81 (0.36 to 1.86) 0.62 (0.26 to 1.46) 0.88 (0.35 to 2.21) 1.11 (0.46 to 2.67)
  P-trend      0.42 0.20 0.64 0.91
Peri/post-menopausal 1 492 30 8,593 349 1.00 1.00 1.00 1.00
  2 307 24 4,848 495 0.86 (0.51 to 1.45) 0.87 (0.51 to 1.47) 0.93 (0.52 to 1.67) 0.94 (0.53 to 1.67)
  3 464 27 8,960 301 0.93 (0.56 to 1.56) 0.94 (0.56 to 1.58) 1.13 (0.65 to 1.98) 1.14 (0.66 to 1.99)
  4 516 29 10,308 281 0.88 (0.51 to 1.53) 0.82 (0.47 to 1.43) 0.89 (0.48 to 1.65) 0.97 (0.53 to 1.78)
  P-trend      0.73 0.57 0.94 0.87
  1. Abbreviations: TSH, thyrotropin; RR, relative risk; RR**, relative risk adjusted for age (continuous), menopausal status (in analysis of all women), use of HRT, nulliparity, use of oral contraception, age at menarche, smoking status, alcohol consumption, BMI, height, educational level and marital status. * P < 0.05.