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Table 3 Breast cancer incidence in pre-, peri/postmenopausal and all women in relation to serum T3 levels

From: Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women

Group

T3

(quartile)

Individuals

(n)

Breast cancer

cases

(n)

Person-years

Incidence/100,000

All cases

Cases >3 years following

Baseline examination

      

RR

(CI: 95%)

RR**

(CI: 95%)

RR

(CI: 95%)

RR**

(CI: 95%)

All

1

494

28

10,418

269

1.00

1.00

1.00

1.00

 

2

704

40

14,613

274

1.02 (0.63 to 1.66)

1.12 (0.69 to 1.84)

1.10 (0.66 to 1.83)

0.99 (0.60 to 1.66)

 

3

456

31

9,096

341

1.28 (0.77 to 2.13)

1.42 (0.83 to 2.43)

1.37 (0.78 to 2.42)

1.21 (0.70 to 2.10)

 

4

531

47

10,091

466

1.75 (1.10 to 2.80)*

1.87(1.12 to 3.14)*

1.98 (1.15 to 3.38)*

1.78 (1.10 to 2.90)*

 

P-trend

    

0.007

0.009

0.007

0.008

Premenopausal

1

298

25

6,376

392

1.00

1.00

1.00

1.00

 

2

311

21

6,621

317

0.81 (0.45 to 1.45)

1.00 (0.55 to 1.81)

1.00 (0.53 to 1.87)

0.80 (0.43 to 1.46)

 

3

131

7

2,816

249

0.63 (0.27 to 1.47)

0.71 (0.30 to 1.70)

0.79 (0.33 to 1.91)

0.69 (0.33 to 1.61)

 

4

123

9

2,610

345

0.88 (0.41 to 1.88)

0.92 (0.40 to 2.15)

1.07 (0.45 to 2.50)

0.96 (0.44 to 2.10)

 

P-trend

    

0.49

0.66

0.94

0.99

Peri/post-menopausal

1

196

3

4,042

74

1.00

1.00

1.00

1.00

 

2

393

19

7,992

237

3.24 (0.96 to 10.9)

3.26 (0.96 to 11.1)

2.75 (0.80 to 9.48)

2.90 (0.85 to 9.91)

 

3

325

24

6,281

382

5.21 (1.57 to 17.4)*

5.53 (1.65 to 18.6)*

4.63 (1.35 to 15.8)*

4.39 (1.30 to 14.8)*

 

4

408

38

7,481

508

6.94 (2.14 to 22.5)*

6.87 (2.09 to 22.6)*

6.14 (1.86 to 20.3)*

6.49 (1.99 to 21.1)*

 

P-trend

    

<0.001

<0.001

<0.001

<0.001

  1. Abbreviations: T3, triiodothyronine; RR, relative risk; RR**, relative risk adjusted for age (continuous), menopausal status (in analysis of all women), use of HRT, nulliparity, use of oral contraception, age at menarche, smoking status, alcohol consumption, BMI, height, educational level and marital status, * P < 0.05.