Correlation between necrotic volumes and STL-6014 accumulation in MDA-MB-231-RFP tumors. CD-1 nude, female mice bearing MDA-MB-231-RFP tumors orthotopically grafted to the mammary fat pad were intravenously injected with STL-6014 (15 mg/kg). Images of large (animals #1,2) and small (animals #3,4) tumors were taken at seven and five days, respectively, post-injection. (a) Red fluorescence protein (RFP) fluorescence images indicate tumor size and location. (b and c) Near infrared (NIR) fluorescence images demonstrating STL-6014 distribution both in vivo and after dissection, respectively. (d) Color photos. (e) Tissue sections of the tumor center stained with hematoxylin and eosin.