Table 2 Main glycosyltransferases involved in biosynthesis of gangliosides
From: Tumour-associated carbohydrate antigens in breast cancer
Gene name | Common name | Accession number | Main acceptor substrate |
|---|---|---|---|
Glucosyltransferase | Â | Â | Â |
   UGCG | GlcCer synthase | NM 003358.1 | Ceramide (Cer) |
Galactosyltransferases | Â | Â | Â |
   B4GALT6 | LacCer synthase | NM_004775 | Glcα1-Cer |
   B3GALT4 | β3-GalT4 | NM_003782.3 | GalNAcβ1-4 [NeuAc0-3]Galβ1-4Glcα1-Cer |
N-Acetyl-galactosaminyltransferase | Â | Â | Â |
   B4GALNACT1 | GM2, GD2, GT2 synthase | NM_001478.2 | [NeuAc0-3]Galβ1-4Glcα1-Cer |
Sialyltransferases | Â | Â | Â |
   ST3GAL1 | ST3Gal I | NM_003033.3 | Galβ1-3GalNAcβ1-4 [NeuAc0-3]Galβ1-4Glcα1-Cer |
   ST3GAL2 | ST3Gal II | NM_006927.3 | Galβ1-3GalNAcβ1-4 [NeuAc0-3]Galβ1-4Glcα1-Cer |
   ST3GAL5 | ST3Gal V | NM_003896.3 | Galβ1-4Glcα1-Cer |
   ST6GALNAC5 | ST6GalNAc V | NM_030965.1 | NeuAca2-3Galβ1-3GalNAcβ1-4Galβ1-4Glcα1-Cer |
   ST8SIA1 | ST8Sia I | NM_003034.3 | NeuAca2-3Galβ1-4Glcα1-Cer |
   ST8Sia5 | ST8Sia V | NM_013305.4 | NeuAca2-8NeuAca2-3Galβ1-4Glcα1-Cer |