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Table 3 Carrier mutation probabilities when the ER status of the mother is unknown, negative or positive

From: Incorporating tumour pathology information into breast cancer risk prediction algorithms

  

Mother's age at diagnosis

Proband age at diagnosis

Mother's ER status

30 years

40 years

50 years

60 years

70 years

  

BRCA 1

BRCA2

BRCA1

BRCA2

BRCA1

BRCA2

BRCA1

BRCA2

BRCA1

BRCA2

30 years

Unknown

0.45

0.16

0.24

0.14

0.15

0.10

0.09

0.09

0.06

0.10

 

ER-negative

0.63

0.11

0.46

0.10

0.36

0.08

0.25

0.08

0.19

0.09

 

ER-positive

0.13

0.25

0.08

0.17

0.04

0.11

0.04

0.10

0.03

0.10

40 years

Unknown

0.23

0.14

0.11

0.10

0.07

0.07

0.04

0.06

0.03

0.07

 

ER-negative

0.38

0.11

0.24

0.08

0.18

0.06

0.12

0.05

0.09

0.06

 

ER-positive

0.05

0.16

0.03

0.10

0.02

0.07

0.02

0.06

0.01

0.07

50 years

Unknown

0.12

0.08

0.06

0.06

0.04

0.04

0.02

0.04

0.02

0.04

 

ER-negative

0.22

0.08

0.14

0.05

0.11

0.04

0.07

0.03

0.06

0.04

 

ER-positive

0.02

0.09

0.01

0.06

0.01

0.04

0.01

0.04

0.01

0.04

60 years

Unknown

0.06

0.07

0.03

0.04

0.02

0.03

0.01

0.03

0.01

0.04

 

ER-negative

0.11

0.06

0.07

0.04

0.06

0.03

0.04

0.03

0.03

0.04

 

ER-positive

0.01

0.07

0.01

0.05

0.00

0.03

0.00

0.03

0.00

0.04

70 years

Unknown

0.03

0.07

0.01

0.05

0.01

0.03

0.01

0.03

0.00

0.04

 

ER-negative

0.06

0.07

0.04

0.05

0.03

0.03

0.02

0.03

0.02

0.04

 

ER-positive

0.01

0.07

0.00

0.05

0.00

0.03

0.00

0.03

0.00

0.04

  1. Both mother and proband are affected and the age of diagnosis of cancer in each case is the same as the age of last follow-up. Figures in italics represent genotype-specific risk when the oestrogen (ER) status is unknown. Bold figures indicate genotype-specific risk <10% when the ER status is unknown, but >10% when the ER status is known.