From: Incorporating tumour pathology information into breast cancer risk prediction algorithms
 |  | Mother's age at diagnosis | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Proband age at diagnosis | Mother's ER status | 30 years | 40 years | 50 years | 60 years | 70 years | |||||
 |  | BRCA 1 | BRCA2 | BRCA1 | BRCA2 | BRCA1 | BRCA2 | BRCA1 | BRCA2 | BRCA1 | BRCA2 |
30 years | Unknown | 0.45 | 0.16 | 0.24 | 0.14 | 0.15 | 0.10 | 0.09 | 0.09 | 0.06 | 0.10 |
 | ER-negative | 0.63 | 0.11 | 0.46 | 0.10 | 0.36 | 0.08 | 0.25 | 0.08 | 0.19 | 0.09 |
 | ER-positive | 0.13 | 0.25 | 0.08 | 0.17 | 0.04 | 0.11 | 0.04 | 0.10 | 0.03 | 0.10 |
40 years | Unknown | 0.23 | 0.14 | 0.11 | 0.10 | 0.07 | 0.07 | 0.04 | 0.06 | 0.03 | 0.07 |
 | ER-negative | 0.38 | 0.11 | 0.24 | 0.08 | 0.18 | 0.06 | 0.12 | 0.05 | 0.09 | 0.06 |
 | ER-positive | 0.05 | 0.16 | 0.03 | 0.10 | 0.02 | 0.07 | 0.02 | 0.06 | 0.01 | 0.07 |
50 years | Unknown | 0.12 | 0.08 | 0.06 | 0.06 | 0.04 | 0.04 | 0.02 | 0.04 | 0.02 | 0.04 |
 | ER-negative | 0.22 | 0.08 | 0.14 | 0.05 | 0.11 | 0.04 | 0.07 | 0.03 | 0.06 | 0.04 |
 | ER-positive | 0.02 | 0.09 | 0.01 | 0.06 | 0.01 | 0.04 | 0.01 | 0.04 | 0.01 | 0.04 |
60 years | Unknown | 0.06 | 0.07 | 0.03 | 0.04 | 0.02 | 0.03 | 0.01 | 0.03 | 0.01 | 0.04 |
 | ER-negative | 0.11 | 0.06 | 0.07 | 0.04 | 0.06 | 0.03 | 0.04 | 0.03 | 0.03 | 0.04 |
 | ER-positive | 0.01 | 0.07 | 0.01 | 0.05 | 0.00 | 0.03 | 0.00 | 0.03 | 0.00 | 0.04 |
70 years | Unknown | 0.03 | 0.07 | 0.01 | 0.05 | 0.01 | 0.03 | 0.01 | 0.03 | 0.00 | 0.04 |
 | ER-negative | 0.06 | 0.07 | 0.04 | 0.05 | 0.03 | 0.03 | 0.02 | 0.03 | 0.02 | 0.04 |
 | ER-positive | 0.01 | 0.07 | 0.00 | 0.05 | 0.00 | 0.03 | 0.00 | 0.03 | 0.00 | 0.04 |