Incorporating tumour pathology information into breast cancer risk prediction algorithms

Breast Cancer Research

Table 1 Oestrogen receptor-negative tumours as a proportion of total tumours in BRCA1 and BRCA2 mutation carriers

Carrier	<30 years old	30 to 39 years old	40 to 49 years old	50 to 59 years old	60 to 69 years old	>70 years old
BRCA1	0.93	0.91	0.86	0.89	0.83	0.83^a
BRCA2 ^a	0.44	0.26	0.47	0.14	0.20	0.15

Data from the Breast Cancer Linkage Consortium (BCLC) [10]. ^aAs numbers were sparse, data were extrapolated from the nearest age group for BRCA1 carriers in updating the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, and population data were substituted for BCLC data for BRCA2 carriers.

ISSN: 1465-542X