Table 3 Preclinical activity of ixabepilone in drug-resistant cancer
From: Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone
Active against numerous drug-resistant tumor cell lines, including human paclitaxel-resistant breast cancer cell lines and xenografts [23, 76–78] |
Inhibitory activity in breast cancers with primary or acquired resistance [23, 78] |
Low susceptibility to multiple mechanisms of drug resistance [23, 76] |
Multidrug resistance overexpression: overexpression of the βIII-tubulin isotype |
Poor substrate for multidrug resistance; does not strongly induce P-glycoprotein expression [12] |