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Table 2 Genotype frequencies

From: Cyclophosphamide- metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study

SNP Variants Genotypes White
# (%)
(n = 314)
Black
# (%)
(n = 19)
Other
# (%)
(n = 17)
P-value1
CYP2B6 All WT 516 G/G 114 (36) 4 (21) 4 (23) 0.14
(rs2279343,   785 A/A     
rs3211371,   1459 C/C     
rs3745274) Any Var Any Var 189 (60) 15 (79) 11 (65)  
  Missing   11 (4) 0 (0) 2 (12)  
CYP2C9 All Wild- 430 C/C 176 (56) 17 (89) 9 (53) 0.06
(rs1799853, type 1075 A/A     
rs1057910) Any Var Any Var 107 (34) 2 (11) 7 (41)  
  Missing   31 (10) 0 (0) 1 (6)  
CYP2D6*4 *1/*1 A/A 19 (6) 0 (0) 0 (0) 0.81
(rs3892097) *1/*4 G/A 86 (27) 4 (21) 4 (27)  
  *4/*4 G/G 198 (63) 15 (79) 11 (63)  
  Missing   11 (4) 0 (0)   
CYP3A4*1B *1A/*1A A/A 281 (89) 5 (26) 13 (76) <0.001
(rs2740574) *1A/*1B G/A 20 (6) 7 (37) 2 (12)  
  *1B/*1B G/G 3 (1) 7 (37) 0 (0)  
  Missing   10 (3) 0 (0) 2 (12)  
CYP3A5*3 *1/*1 A/A 4 (1) 9 (47) 0 (0) <0.001
(rs776746) *1/*3 G/A 39 (12) 8 (42) 5 (29)  
  *3/*3 G/G 260 (83) 1 (5) 11 (65)  
  Missing   11 (4) 1 (5) 1 (6)  
CYP3A5*6 *1/*1 G/G 307 (98) 15 (79) 16 (94) <0.001
(rs10264272) *1/*6 A/G 1 (<1) 4 (21) 0 (0)  
  *6/*6 A/A 0 (0) 0 (0) 0 (0)  
  Missing   6 (2) 0 (0) 1 (6)  
GSTM1 Non-null   135 (43) 11 (58) 9 (53) 0.09
  Null   171 (54) 7 (37) 6 (35)  
  Missing   8 (3) 1 (5) 2 (12)  
GSTT1 Non-null   254 (81) 10 (53) 13 (76) 0.02
  Null   51 (16) 8 (42) 2 (12)  
GSTT1 Missing   9 (3) 1 (5) 2 (12)  
GSTP1 All WT Ex 5-24A/A 146 (47) 6 (32) 7 (41) 0.11
(rs1695, rs1138272)   Ex 6+5 C/C     
  Any Var Any Variant 160 (51) 13 (68) 8 (47)  
  Missing   8 (3) 0 (0) 2 (1)  
Combined CYP-GST genotype Favorable   0 (0) 0 (0) 0 (0) 0.06
groups Intermediate   186 (60) 15 (79) 6 (35)  
  Unfavorable   102 (32) 3 (16) 8 (47)  
  Missing   26 (8) 1 (5) 3 (18)  
  1. 1 Exact Pearson's or Chi-square test
  2. SNP: single nucleotide polymorphism