Table 2 Genotype frequencies
| SNP | Variants | Genotypes |
White # (%) (n = 314) |
Black # (%) (n = 19) |
Other # (%) (n = 17) | P-value1 |
|---|---|---|---|---|---|---|
| CYP2B6 | All WT | 516 G/G | 114 (36) | 4 (21) | 4 (23) | 0.14 |
| (rs2279343, | 785 A/A | |||||
| rs3211371, | 1459 C/C | |||||
| rs3745274) | Any Var | Any Var | 189 (60) | 15 (79) | 11 (65) | |
| Missing | 11 (4) | 0 (0) | 2 (12) | |||
| CYP2C9 | All Wild- | 430 C/C | 176 (56) | 17 (89) | 9 (53) | 0.06 |
| (rs1799853, | type | 1075 A/A | ||||
| rs1057910) | Any Var | Any Var | 107 (34) | 2 (11) | 7 (41) | |
| Missing | 31 (10) | 0 (0) | 1 (6) | |||
| CYP2D6*4 | *1/*1 | A/A | 19 (6) | 0 (0) | 0 (0) | 0.81 |
| (rs3892097) | *1/*4 | G/A | 86 (27) | 4 (21) | 4 (27) | |
| *4/*4 | G/G | 198 (63) | 15 (79) | 11 (63) | ||
| Missing | 11 (4) | 0 (0) | ||||
| CYP3A4*1B | *1A/*1A | A/A | 281 (89) | 5 (26) | 13 (76) | <0.001 |
| (rs2740574) | *1A/*1B | G/A | 20 (6) | 7 (37) | 2 (12) | |
| *1B/*1B | G/G | 3 (1) | 7 (37) | 0 (0) | ||
| Missing | 10 (3) | 0 (0) | 2 (12) | |||
| CYP3A5*3 | *1/*1 | A/A | 4 (1) | 9 (47) | 0 (0) | <0.001 |
| (rs776746) | *1/*3 | G/A | 39 (12) | 8 (42) | 5 (29) | |
| *3/*3 | G/G | 260 (83) | 1 (5) | 11 (65) | ||
| Missing | 11 (4) | 1 (5) | 1 (6) | |||
| CYP3A5*6 | *1/*1 | G/G | 307 (98) | 15 (79) | 16 (94) | <0.001 |
| (rs10264272) | *1/*6 | A/G | 1 (<1) | 4 (21) | 0 (0) | |
| *6/*6 | A/A | 0 (0) | 0 (0) | 0 (0) | ||
| Missing | 6 (2) | 0 (0) | 1 (6) | |||
| GSTM1 | Non-null | 135 (43) | 11 (58) | 9 (53) | 0.09 | |
| Null | 171 (54) | 7 (37) | 6 (35) | |||
| Missing | 8 (3) | 1 (5) | 2 (12) | |||
| GSTT1 | Non-null | 254 (81) | 10 (53) | 13 (76) | 0.02 | |
| Null | 51 (16) | 8 (42) | 2 (12) | |||
| GSTT1 | Missing | 9 (3) | 1 (5) | 2 (12) | ||
| GSTP1 | All WT | Ex 5-24A/A | 146 (47) | 6 (32) | 7 (41) | 0.11 |
| (rs1695, rs1138272) | Ex 6+5 C/C | |||||
| Any Var | Any Variant | 160 (51) | 13 (68) | 8 (47) | ||
| Missing | 8 (3) | 0 (0) | 2 (1) | |||
| Combined CYP-GST genotype | Favorable | 0 (0) | 0 (0) | 0 (0) | 0.06 | |
| groups | Intermediate | 186 (60) | 15 (79) | 6 (35) | ||
| Unfavorable | 102 (32) | 3 (16) | 8 (47) | |||
| Missing | 26 (8) | 1 (5) | 3 (18) |