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Table 1 Patient and tumor characteristics for the 200 HER2+ tumors and the 554 HER2- reference breast cancer data set

From: High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer

  HER2+ HER2-*
Number of tumors 200 554
Number of primary tumors 176 --
Number of metastases 5 --
Unknown status 19 --
Tumor size   
≤20 mm 57 205
>20 mm 134 226
Mean size mm (SD) 29 (16) 26 (14)
Histological grade   
Grade 1 1 41
Grade 2 26 134
Grade 3 38 134
Estrogen receptor status   
Positive 76 306
Negative 122 149
Lymph node status   
Negative 69 244
Positive 123 194
Age   
Median age in years (range) 56 (27 to 84) 55 (28 to 94)
<50 years 77 212
≥50 years 109 252
DNA ploidy status   
Aneuploid 112 --
Diploid 39 --
Unknown 49 --
Gene expression subtype**   
Basal-like 7 135
ERBB2 51 6
Normal-like 9 35
Luminal A 4 153
Luminal B 10 77
Unclassified 6 42
Overall survival***   
Number of deaths 109 190
Within five years 80 107
Median survival in years (range) 7 (0.16 to 18.5) 7.6 (0.1 to 31.9)
Median follow-up in years for patients still alive (range) 12.8 (7 to 18.5) 10.2 (1.5 to 20.2)
  1. *: The HER2- data set is composed of four individual data sets as described in Material and methods.
  2. **: Classification in gene expression subtypes according to Hu et al. [41].
  3. ***: For primary HER2+ tumors only.