Figure 5

Association of OS with TOP2A-status, HER2 copy number levels, and GISTIC regions in HER2+ and HER2- tumors. (A) OS in primary HER2+ tumors stratified by TOP2A-status. (B) OS in primary HER2+ tumors stratified by the 25^th (HER2+ CN low) and 75^th percentile (HER2+ CN high) of the mean HER2 segmented log₂ratio. (C) OS in primary HER2+ tumors stratified by the 15^th (HER2+ CN low) and 85^th percentile (HER2+ CN high) of the mean HER2 log₂ratio. (D) GISTIC regions showing association with OS (log-rank P < 0.1) in the 176 primary HER2+ tumors. The vertical axis represents -log₁₀(p) for log-rank, univariate and multivariate analysis. Tumor size and LN status were included as covariates in multivariate analyses beside GISTIC regions. Dashed lines indicate P = 0.1, 0.05 and 0.01. GISTIC regions are ordered according to their genomic position. (E) Association to OS for GISTIC regions in D in HER2- tumors. The vertical axis represents -log₁₀(p) for log-rank, univariate and multivariate analysis. Tumor size and LN status were included as covariates in multivariate analyses besides GISTIC regions. Dashed lines indicate P = 0.1, 0.05 and 0.01. GISTIC regions are ordered according to their genomic position.