Effects of childhood body size on breast cancer tumour characteristics

Breast Cancer Research

Table 1 Associations of somatotype at age seven years with other breast cancer risk factors (controls only)

Risk factor (dependent variable)	Somatotype (independent variable)	n	OR	95% CI		Ptrend*
Age of menarche (years)	Lean	1456	1.00	reference		<0.0001
	Medium	669	0.72	0.64	0.82
	Large	187	0.61	0.50	0.76
Age of menopause (years)	Lean	1572	1.00	reference		0.697
	Medium	736	1.19	0.85	1.68
	Large	204	0.93	0.53	1.65
Parity (Number of live births)	Lean	1578	1.00	reference		0.217
	Medium	745	0.93	0.83	1.05
	Large	207	0.93	0.76	1.13
Benign breast disease	Lean	1578	1.00	reference		0.006
	Medium	745	0.76	0.56	1.03
	Large	207	0.47	0.25	0.89
Somatotype one year prior to enrolment	Lean	1571	1.00	reference		<0.0001
	Medium	739	1.72	1.44	2.05
	Large	206	2.33	1.70	3.18
BMI (kg/m²)	Lean	1562	1.00	reference		<0.0001
	Medium	742	1.85	1.30	2.65
	Large	205	2.66	1.47	4.83
Percent mammographic density (%)†	Lean	862	1.00	reference		0.001
	Medium	428	0.72	0.58	0.91
	Large	108	0.61	0.41	0.90
HRT	Lean	1569	1.00	reference		0.868
	Medium	739	0.99	0.83	1.18
	Large	206	0.98	0.73	1.32
	Other independent variables
Birthweight (g) on somatotype at age 7	≤2500	49	1.00	reference		0.014
	2500-3000	229	1.18	0.61	2.29
	3000-3500	470	1.29	0.68	2.43
	3500-4000	397	1.44	0.76	2.73
	>4000	135	1.89	0.95	3.76
Family history on somatotype at age 7	No	2258	1.00	reference		0.485
	Yes	227	1.10	0.84	1.44

* Based on Wald tests for regression coefficients in continuous, ordinal or logistic regression models (see statistical analyses section). All regression models were adjusted for age at enrolment. † Subset with phenotypic data. BMI, body mass index; CI, confidence interval; HRT, hormone replacement therapy; OR, odds ratio.

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