Figure 1

Comparison of analogous human and mouse mammary cell subsets. Representative FACS dotplots of (a) Lin^- human mammary cells isolated from the reduction mastectomy specimen of a 27-year-old woman labeled with CD49f and EpCAM antibodies and (b) Lin^- mouse mammary cells isolated from 8-week-old virgin FVB/N mice labeled with CD24, CD29, and CD61 antibodies. The four analogous mammary subsets correspond to the MaSC-enriched (human CD49f^hiEpCAM^-; mouse CD29^hiCD24⁺CD61⁺), luminal progenitor (human CD49f⁺EpCAM⁺; mouse CD29^loCD24⁺CD61⁺), mature luminal (human CD49f^-EpCAM⁺; mouse CD29^loCD24⁺CD61^-), and stromal (human CD49f^-EpCAM^-; mouse CD29^loCD24^-) mammary cell subpopulations. LP: luminal progenitor; Lum: luminal; ML: mature luminal; MS: MaSC-enriched; Str: stromal.