Table 1 The type and frequency of mutations in phosphatidylinositol 3-kinase (PI3K) pathway components in breast cancer
PI3K component | Type of mutation | Incidence |
|---|---|---|
P110a (PIK3CA) | Mutation | 27% |
P110α (PIK3CA) | Amplification | 8.7% |
P110β (PIK3CB) | Amplification | 5% |
PDPK1 | Amplification and overexpression | 20% |
AKT1 | Mutation (E17K) | 3.7% |
AKT2 | Amplification | 3% |
PTEN | Loss of heterozygosity | 24.9% |
PTEN | Mutation | 6% |