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Table 3 Global genetic association tests between SNPs in the estrogen metabolic pathways and mammographic breast density

From: Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer

Pathway

Number of SNPs

P heterogeneity

P trenda

Whole pathway

239

0.840

0.507

Androgen synthesis

11

0.761

0.763

Androgen to estrogen conversion

120

0.587

0.715

Estrogen removal

134

0.834

0.872

  1. aP values based on 5,000 permutations.