Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer

Table 2 Significant SNPs in the estrogen metabolic pathway, corresponding regression coefficients and P values

SNP	Gene	Minor allele	MAF	n	Coefficient	SE	P value
rs11638442	CYP11A1	C	0.35	1,677	0.0557	0.0212	0.0088
rs16968478	CYP11A1	G	0.17	1,703	0.0575	0.0263	0.0293
rs2279357	CYP11A1	A	0.20	1,699	0.0511	0.0229	0.0260
rs2959003	CYP11A1	A	0.28	1,669	0.0582	0.0224	0.0094
rs2959008	CYP11A1	A	0.30	1,703	0.0475	0.0221	0.0315
rs2066485	HSD17B3	G	0.14	1,703	0.0668	0.0293	0.0230
rs7039978	HSD17B3	A	0.50	1,694	--0.0632	0.0203	0.0019
rs1469908	NQO1	C	0.37	1,695	--0.0472	0.0206	0.0223
rs17268974	STS	A	0.22	1,605	0.0503	0.0238	0.0349
rs2270112	STS	C	0.34	1,686	--0.0485	0.0208	0.0197
rs707762	STS	A	0.40	1,687	0.0435	0.0205	0.0340

P values from a one-degree-of-freedom likelihood ratio test. MAF, minor allele frequency; SE, standard error.

ISSN: 1465-542X