From: Effects of lovastatin on breast cancer cells: a proteo-metabonomic study
MDAMB468 cells | Control vs. lactone | Control vs. acid |
---|---|---|
14-3-3 beta | 3.51 | 1.93 |
14-3-3 zeta/theta | 1.61 | 1.48 |
17-beta hydroxysteroid dehydrogenase | 0.62 | 0.47 |
6-phosphogluconolactonase | 1.56 | 1.5 |
alpha enolase | 1.89 | 1.37 |
alpha glucosidase subunit alpha isoform 3 | 0.64 | 0.4 |
ATPase, H+ transporting, lysosomal 70 kDa V1 subunit A | 0.30 | 0.31 |
ATP citrate lyase beta, mitochondrial | 0.33 | 0.63 |
Carbonyl reductase [NADPH] 3 | 3.00 | 1.56 |
Chaperonin containing TCP1, subunit 6A | 1.34 | 1.98 |
chloride intracellular channel 1 | 1.2 | 2.12 |
cofilin 1/2 | 0.60 | 0.65 |
D3-phosphoglycerate dehydrogenase | 0.75 | 0.16 |
DJ-1 | 0.54 | 0.45 |
EEF1 delta | 0.68 | 0.4 |
ER-60 protein | 2.18 | 1.56 |
eukaryotic initiation factor 4A-II | 0.35 | 0.63 |
eukaryotic translation initiation factor 3 subunit H | 0.71 | 0.49 |
eukaryotic translation initiation factor 6 | 4.76 | 1.57 |
Ezrin | 2.10 | 4.00 |
gelsolin precursor | 2.73 | 1.54 |
glutamate receptor GRIA3 | 0.24 | 0.63 |
glycyl-tRNA synthetase | 0.40 | 0.33 |
heat shock cognate 71 kDa protein | 0.20 | 0.36 |
IMMT (mitochondrial inner membrane protein) | 3.44 | 2.32 |
lamin A/C, isoform CRA_c | 0.41 | 0.47 |
MAPRE1 protein | 0.86 | 0.4 |
multidrug resistance-associated protein MGr1-Ag | 0.52 | 0.74 |
NADH dehydrogenase Fe-S protein 1, 75 kDa | 0.56 | 0.35 |
nucleoside phosphorylase | 1.95 | 1.31 |
protein disulfide isomerase associated 6 | 0.85 | 0.41 |
protein disulfide isomerase ER-60 | 2.13 | 1.25 |
RAB8b, member RAS oncogene family | 3.16 | 1.48 |
RAVER-1 protein | 2.17 | 1.60 |
splicing factor, arginine/serine-rich 1 | 0.24 | 0.71 |
sterol carrier protein X/2 | 0.45 | 0.52 |
stress-70 protein, mitochondrial precursor (observed pI 5.9; theoretical pI 5.9) | 0.65 | 0.57 |
stress-70 protein, mitochondrial precursor (observed pI 5.6; theoretical pI 5.9) | 0.59 | 0.42 |
succinate dehydrogenase [ubiquinone] flavoprotein subunit | 0.59 | 0.3 |
triosephosphate isomerase (pI observed 6.7; theoretical pI 6.5) | 0.70 | 0.64 |
thioredoxin domain-containing protein 12 | 0.64 | 0.7 |
RhoA precursor | 0.65 | 0.6 |
MDAMB231 cells | Â | Â |
3-hydroxyisobutyrate dehydrogenase, mitochondrial | 0.64 | 0.73 |
aldose reductase | 1.64 | 1.40 |
alpha enolase | 0.28 | absent |
annexin A1 (observed pI 6.6; theoretical pI 6.6) | 1.67 | 1.42 |
annexin A1 (observed pI 6.4; theoretical pI 6.6) | 1.24 | 3.08 |
annexin A4 | 1.52 | 1.63 |
cathepsin D precursor | 0.55 | 0.52 |
cell division cycle protein 42 | 1.76 | 2.04 |
chloride intracellular channel protein 1 (observed pI 5.1; theoretical pI 5.1) | 1.58 | 1.98 |
chloride intracellular channel protein 1 (observed pI 5.3; theoretical pI 5.1) | 1.61 | 1.97 |
Cleavage stimulation factor 64 kDa subunit | 0.28 | 0.35 |
cofilin 1/2 | 0.62 | 0.71 |
complement component 1 Q subcomponent-binding protein, mitochondrial | 0.41 | 0.63 |
Cytochrome b-c1 complex subunit 1, mitochondrial | 0.71 | 0.63 |
Cytochrome c-type heme lyase | 0.35 | 0.37 |
dihydrolipoamide S-acetyltransferase, component of PDH complex | 0.60 | 0.68 |
DJ-1 | 0.34 | 0.44 |
elongation factor 1-delta | 0.85 | 0.24 |
endoplasmic reticulum protein ERp29 precursor | 1.36 | 1.60 |
eukaryotic translation initiation factor 3 subunit I | 0.70 | 0.73 |
Ezrin | 2.31 | 1.77 |
GDP dissociation inhibitor 2 | 1.6 | 1.54 |
gelsolin precursor (identified in 3 spots as fragment) | 1.77 | 1.80 |
glutathione S-transferase Pi | 1.56 | 1.84 |
glutathione S-transferase omega-1 | 1.65 | 1.57 |
glycyl-tRNA synthetase | 1.91 | 1.41 |
GrpE protein homolog 1, mitochondrial precursor | 0.67 | 0.76 |
heat shock protein 27 | 1.33 | 1.57 |
heterogeneous nuclear ribonucleoprotein F | 0.72 | 0.95 |
heterogeneous nuclear ribonucleoprotein H1 | 1.91 | 2.32 |
heterogeneous nuclear ribonucleoprotein K | 0.41 | 0.24 |
heterogeneous nuclear ribonucleoproteins C1/C2 | 0.56 | 0.91 |
high mobility group protein B1 | 2.59 | 1.94 |
interferon-induced GTP-binding protein Mx2 | 1.24 | 1.59 |
Ku70 antigen | 0.46 | 0.35 |
lactoyl-glutathione lyase | 1.82 | 2.02 |
lamin-A/C | 0.36 | 0.45 |
LIM and SH3 domain protein 1 | 1.73 | 1.75 |
macrophage-capping protein (identified in two spots) | 2.00 | 1.98 |
minichromosome maintenance protein 7 | 0.44 | 0.28 |
moesin | 0.53 | 1.02 |
MutS homolog 2 | 0.35 | 0.16 |
nucleophosmin | 0.61 | 0.22 |
peroxiredoxin 2 | 1.56 | 1.58 |
peroxiredoxin 3 | 1.63 | 1.81 |
plexin-D1 precursor | 0.30 | 0.53 |
pre-mRNA-processing factor 19 | 0.76 | 0.48 |
prohibitin | 1.75 | 1.59 |
proliferating cell nuclear antigen | 0.15 | 0.49 |
proteasome activator complex subunit 1 | 1.20 | 1.40 |
proteasome activator complex subunit 3 | 0.49 | 0.39 |
protein NDRG1 | 1.69 | 1.58 |
putative ATP-dependent Clp protease proteolytic subunit, mitochondrial | 0.59 | 0.76 |
Ran-specific GTPase-activating protein | 1.54 | 1.66 |
Ras GTPase-activating protein-binding protein 1 | 0.54 | 0.48 |
reticulocalbin-1 precursor (identified in two spots as fragment) | 0.47 | 0.64 |
reticulocalbin-1 precursor | 0.58 | 0.78 |
stomatin-like protein 2 | 0.64 | 0.52 |
stress-70 protein, mitochondrial (observed pI 5.9; theoretical pI 5.9) | 0.61 | 0.74 |
stress-70 protein, mitochondrial precursor (observed pI 5.4; theoretical pI 5.9) | 0.59 | 0.42 |
synaptic vesicle membrane protein VAT-1 homolog | 5.14 | 4.55 |
RhoA precursor | 0.49 | 0.65 |
TRAP1 | 1.54 | 1.76 |
triosephosphate isomerase (pI observed 6.2; theoretical pI 6.5) | 2.37 | 2.14 |
triosephosphate isomerase (pI observed 6.5; theoretical pI 6.5) | 0.77 | 0.59 |
tropomyosin 1 alpha chain isoform 4 | 0.31 | 0.44 |
vinculin | 2.12 | 2.69 |
zyxin | 2.39 | 0.82 |