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Figure 5 | Breast Cancer Research

Figure 5

From: Effects of lovastatin on breast cancer cells: a proteo-metabonomic study

Figure 5

Western blot analysis of proteins involved in regulation of apoptosis and AKT-signaling. Breast cancer cell lines MDAMB231 and MDAMB468 were treated with 8 μg/mL lovastatin lactone (Lova Lac) or lovastatin acid (Lova Ac) for 48 hours. For key proteins, western blot analysis of phosphatase and tensin homolog (PTEN), pAkt and N-myc downstream regulated gene 1 (NDRG1) was performed based on MDAMB231 cell extracts, otherwise both cell lines are shown. Densitometry data were normalized based on the amount of β-actin. Data are presented as means ± standard deviations (n = 3) *P < 0.05;**P < 0.05; ***P < 0.001). Gel images were cropped to improve the clarity and conciseness of the presentation. PCNA, proliferating cell nuclear antigen.

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