MicroRNAs and their target gene networks in breast cancer

Breast Cancer Research

Table 1 miRNAs and their targets in breast cancer cells

miRNA	Target	Functional pathway	Reference
Tumor suppressor miRNAs
miR-206	ESR1	ER signaling	[28, 33]
miR-17-5p	AIB1, CCND1, E2F1	Proliferation	[37, 38]
miR-125a, b	HER2, HER3	Anchorage-dependent growth	[40, 41]
miR-200	BMI1, ZEB1, ZEB2	TGF-β signaling	[47, 52, 54]
let-7	H-RAS, HMGA2, LIN28, PEBP1	Proliferation, differentiation	[73–75]
miR-34a	CCND1, CDK6, E2F3, MYC	DNA damage, proliferation	[76–78]
miR-31	FZD3, ITGA5, M-RIP, MMP16, RDX, RHOA	Metastasis	[61]
Oncogenic miRNAs
miR-21	BCL-2, TPM1, PDCD4, PTEN, MASPIN	Apoptosis	[64–67]
miR-155	RHOA	TGF-β signaling	[68]
miR-10b	HOXD10	Metastasis	[69]
miR-373/520c	CD44	Metastasis	[79]

miRNAs and their targets in breast cancer. Several studies have identified altered miRNA expression profiles in breast cancer. The loss of several tumor suppressor miRNAs and overexpression of oncogenic miRNAs leads to loss of regulation of several cellular functions that may be involved in breast cancer pathogenesis.

ISSN: 1465-542X