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Table 1 miRNAs and their targets in breast cancer cells

From: MicroRNAs and their target gene networks in breast cancer

miRNA Target Functional pathway Reference
Tumor suppressor miRNAs    
   miR-206 ESR1 ER signaling [28, 33]
   miR-17-5p AIB1, CCND1, E2F1 Proliferation [37, 38]
   miR-125a, b HER2, HER3 Anchorage-dependent growth [40, 41]
   miR-200 BMI1, ZEB1, ZEB2 TGF-β signaling [47, 52, 54]
   let-7 H-RAS, HMGA2, LIN28, PEBP1 Proliferation, differentiation [7375]
   miR-34a CCND1, CDK6, E2F3, MYC DNA damage, proliferation [7678]
   miR-31 FZD3, ITGA5, M-RIP, MMP16, RDX, RHOA Metastasis [61]
Oncogenic miRNAs    
   miR-21 BCL-2, TPM1, PDCD4, PTEN, MASPIN Apoptosis [6467]
   miR-155 RHOA TGF-β signaling [68]
   miR-10b HOXD10 Metastasis [69]
   miR-373/520c CD44 Metastasis [79]
  1. miRNAs and their targets in breast cancer. Several studies have identified altered miRNA expression profiles in breast cancer. The loss of several tumor suppressor miRNAs and overexpression of oncogenic miRNAs leads to loss of regulation of several cellular functions that may be involved in breast cancer pathogenesis.